Author

S. Caim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 7 Approach:statistical model· 6 Approach:experimental assay· 5 Assay:metagenomics· 5 Organism:human· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3

Frequent Co-Authors

L. J. Hall· 10 shared C. Alcon-Giner· 5 shared C. Leclaire· 5 shared R. Kiu· 5 shared G. Le Gall· 3 shared M. Dalby· 3 shared M. J. Dalby· 3 shared T. Korcsmaros· 3 shared

Activity by Year

2019-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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Curved chords = mutual co-authorship

10 shared papersMicrobiology

L. J. Hall

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Gut microbiota and faecal cytokine profiles of rural Cambodian infants and links to early life nutrition and diarrhoeal episodes.

M. J. Dalby, R. Kiu, I. R. Serghiou, A. Miyazaki, H. Acford-Palmer, R. Tung, S. Caim, S. Phillips, M. Kujawska, M. Matsui, A. Iwamoto, B. Taking, S. E. Cox, L. J. Hall

This study examines gut microbiota and cytokine profiles in rural Cambodian infants, finding associations between breastfeeding, pathogen exposure, and microbial composition.

bioRxiv · Jul 24, 2023 · PreprintMicrobiology

Microbiomes attached to fresh perennial ryegrass- are temporally resilient and adapt to changing ecological niches

S. Huws, J. Edwards, W. Lin, F. Rubino, M. Alston, D. Swarbeck, s. Caim, P. Rees Stevens, J. Pachebat, M.-Y. Won, L. Oyama, C. Creevey, A. KIngston-Smith

This study investigates temporal ecological interactions at the fresh perennial ryegrass-biofilm interface in the rumen using metatranscriptomic profiling, identifying distinct sub-microbiomes and their functional roles.

bioRxiv · Nov 17, 2020Microbiology

Preterm infants harbour diverse Klebsiella populations, including atypical species that encode and produce an array of antimicrobial resistance- and virulence-associated factors

Y. Chen, T. C. Brook, C. Z. Soe, I. O'Neill, C. Alcon-Giner, O. Leelastwattanagul, S. Phillips, S. Caim, P. Clarke, L. J. Hall, L. Hoyles

The paper isolates and characterizes Klebsiella species from preterm infants, revealing diverse species and antimicrobial resistance traits associated with health and disease.

Microbial Genomics · Jun 1, 2020Peer-reviewedMicrobiology

Bifidobacterium breve UCC2003 exopolysaccharide modulates the early life microbiota by acting as a dietary substrate

D. Puengel, A. Treveil, M. J. Dalby, S. Caim, I. J. Colquhoun, C. Booth, J. Ketskemety, T. Korcsmaros, D. van Sinderen, M. A. Lawson, L. J. Hall

This study shows that Bifidobacterium breve UCC2003 exopolysaccharide (EPS) alters infant microbiota and metabolite profiles by serving as a nutrient substrate.

Nutrients · Mar 29, 2020Peer-reviewedMicrobiology

Bifidobacterium breve UCC2003 induces a distinct global transcriptomic programme in neonatal murine intestinal epithelial cells

R. Kiu, A. Treveil, L. C. Harnisch, S. Caim, C. Leclaire, D. van Sinderen, T. Korcsmaros, L. J. Hall

This study shows that Bifidobacterium breve UCC2003 significantly alters the transcriptome of neonatal intestinal epithelial cells, enhancing cell replication, differentiation, and growth.

bioRxiv · Mar 27, 2020Immunology

Antibiotic-induced disturbances of the gut microbiota result in accelerated breast tumour growth via a mast cell-dependent pathway

B. M. Kirkup, A. M. McKee, M. Madgwick, C. A. Price, S. A. Dreger, K. A. Makin, S. Caim, G. Le Gall, J. Pavely, C. Leclaire, M. Dalby, C. Alcon-Giner, A. Andrusaite, M. Di Modica, T. Triulzi, , S. D. Robinson

This study shows antibiotic-induced gut microbiota disturbances accelerate breast tumour growth in mice via mast cell-dependent mechanisms.

bioRxiv · Mar 7, 2020 · PreprintCancer Biology

Microbiota supplementation with Bifidobacterium and Lactobacillus modifies the preterm infant gut microbiota and metabolome

C. Alcon-Giner, M. Dalby, S. Caim, J. Ketskemety, A. Shaw, K. Sim, M. Lawson, R. Kiu, C. Leclaire, L. Chalklen, M. Kujawska, S. Mitra, F. Fardus-Reid, G. Belteki, K. Lloyd, , L. J. Hall

This study shows that supplementing preterm infants with Bifidobacterium and Lactobacillus changes their gut microbiota and increases fecal acetate and lactate levels, resembling a full-term infant's gut environment.

bioRxiv · Oct 4, 2019Microbiology

The early life microbiota protects neonatal mice from pathological small intestinal epithelial cell shedding

K. R. Hughes, Z. Schofield, M. J. Dalby, S. Caim, L. Chalklen, F. Bernuzzi, C. Alcon-Giner, G. Le Gall, A. J. Watson, L. J. Hall

This study shows that early life gut microbiota in mice prevents pathological small intestinal epithelial cell shedding, with antibiotic treatment reversing this protection.

bioRxiv · Oct 2, 2019Microbiology

Genomic analysis on broiler-associated Clostridium perfringens strains and caecal microbiome profiling reveals key factors linked to poultry Necrotic Enteritis

R. Kiu, J. Brown, H. Bedwell, C. Leclaire, S. Caim, D. Pickard, G. Dougan, R. Dixon, L. J. Hall

This study identifies hypervirulent Clostridium perfringens strains and microbiome changes associated with necrotic enteritis in broiler chickens.

bioRxiv · Jul 9, 2019Microbiology

Phylogenomic analysis of Clostridium perfringens identifies isogenic strains in gastroenteritis outbreaks, and novel virulence-related features

R. Kiu, S. Caim, D. Pickard, A. Painset, C. Swift, G. Dougan, A. E. Mather, C. Amar, L. J. Hall

This study uses whole genome sequencing to analyze C. perfringens strains from gastroenteritis outbreaks, identifying isogenic strains and novel virulence features.

bioRxiv · Jun 13, 2019Microbiology

Perturbation of the gut microbiota by antibiotics results in accelerated breast tumour growth and metabolic dysregulation

B. Kirkup, A. McKee, K. Makin, J. Paveley, S. Caim, C. Alcon-Giner, C. Leclaire, M. Dalby, G. Le Gall, A. Andrusaite, P. Kreuzaler, P. Driscoll, J. MacRae, E. Calvani, A. Ghanate, , S. D. Robinson

This study shows that antibiotics disrupt the gut microbiota, leading to faster breast tumour growth and metabolic changes in mice.

bioRxiv · Feb 19, 2019 · PreprintCancer Biology