C. Booth

Dysferlin Regulates Cardiac T-tubule Structure and Excitation-contraction Coupling in Isolated Cardiac Myocytes at Rest and in Response to Acute Hypo-osmotic Stress and is Protective Against Arrhythmias in Langendorff-perfused Hearts

This study shows dysferlin is critical for maintaining cardiac T-tubule structure and EC coupling, and its loss increases arrhythmia risk under stress and during aging.

Genetic and cellular basis of impaired phagocytosis and photoreceptor degeneration in CLN3 disease.

This study investigates how CLN3 mutations impair phagocytosis and cause photoreceptor degeneration in CLN3 disease using patient-derived cells and a miniswine model.

qMAP Enabled Microanatomical Mapping of Human Skin Aging

This study introduces qMAP, a deep learning-based workflow for microanatomical mapping of human skin, identifying 10 core processes strongly associated with aging and achieving age prediction accuracy comparable to epigenetic clocks.

High-fidelity enhanced AsCas12a knock-in mice for efficient multiplexed gene editing, disease modeling and orthogonal immunogenetics

Inhibiting Runx1 protects heart function after myocardial infarction

This study shows that inhibiting RUNX1 improves heart function after myocardial infarction by preserving contractility and mitochondrial function.

Desulfovibrio diazotrophica sp. nov., a sulphate reducing bacterium from the human gut capable of nitrogen fixation

The paper isolates and characterizes a new sulfate-reducing bacterium from the human gut that can fix nitrogen, naming it Desulfovibrio diazotrophica.

Bifidobacterium breve UCC2003 exopolysaccharide modulates the early life microbiota by acting as a dietary substrate

This study shows that Bifidobacterium breve UCC2003 exopolysaccharide (EPS) alters infant microbiota and metabolite profiles by serving as a nutrient substrate.

Differential expression of soluble receptor for advanced glycation end-products (sRAGE) in mice susceptible or resistant to chronic colitis

The paper identifies sRAGE as a protective factor against chronic colitis in mice and humans by comparing resistant and susceptible models and validating findings in clinical samples.