S. Crotta

This study identifies impaired interferon responses as a cause of age-dependent COVID-19 severity and shows that combined IFN-γ and IFN-λ therapy can mitigate disease in aged mice.

This study shows that activating HIF signaling reduces SARS-CoV-2 infection and respiratory symptoms in hamsters by decreasing viral RNA and epithelial damage.

This study examines IFN-I and IFN-III expression patterns in the respiratory tract of COVID-19 patients, finding higher IFN-III levels in severe cases and varying roles across anatomical sites.

This study shows that antibiotic-treated mice are more susceptible to rotavirus due to reduced IL-22 expression, which normally inhibits viral replication through mechanisms independent of IFN signaling.

This study shows that type I and III interferons impair lung epithelial repair during viral infection recovery, increasing disease severity and bacterial susceptibility.