Author

D. Schnepf

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 5 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Ohnemus· 4 shared M. Schwemmle· 3 shared A. Wack· 2 shared J. Beer· 2 shared P. Staeheli· 2 shared S. Crotta· 2 shared A. Breithaupt· 1 shared A. Diefenbach· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersImmunology

A. Ohnemus

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Author profile →

5 papers

Recent·Most cited

Sustained innate interferon is an essential inducer of tertiary lymphoid structures

A. L. Calvanese, V. Cecconi, S. Staehli, D. Schnepf, P. Pereira, J. Gschwend, M. Heikenwaelder, C. Schneider, B. Ludewig, K. Silina, M. van den Broek

This study identifies sustained type I interferon signaling as essential for the development of functional tertiary lymphoid structures in the lungs during inflammation.

bioRxiv · Apr 30, 2024Immunology

IFN-lambda is protective against lethal oral Toxoplasma gondii infection

M. Murillo-Leon, A. M. Bastidas-Quintero, N. S. Endres, D. Schnepf, E. Delgado-Betancourt, A. Ohnemus, G. A. Taylor, M. Schwemmle, P. Staeheli, T. Steinfeldt

This study shows that IFN-lambda protects against lethal oral Toxoplasma gondii infection by enhancing intestinal epithelial and neutrophil responses.

bioRxiv · Feb 24, 2023 · PreprintImmunology

Impaired immune response drives age-dependent severity of COVID-19

J. Beer, S. Crotta, A. Breithaupt, A. Ohnemus, J. Becker, B. Sachs, L. Kern, M. Llorian, N. Ebert, F. Labroussaa, T. T. N. Tran, B. S. Trueeb, J. Jores, V. Thiel, M. Beer, , D. Schnepf

This study identifies impaired interferon responses as a cause of age-dependent COVID-19 severity and shows that combined IFN-γ and IFN-λ therapy can mitigate disease in aged mice.

bioRxiv · Apr 21, 2022Immunology

A broadly neutralizing biparatopic Nanobody protects mice from lethal challenge with SARS-CoV-2 variants of concern

T. R. Wagner, D. Schnepf, J. Beer, K. Klingel, N. Ruetalo, P. D. Kaiser, D. Junker, M. Sauter, B. Traenkle, D. I. Frecot, M. Becker, N. Schneiderhan-Marra, A. Ohnemus, M. Schwemmle, M. Schindler, U. Rothbauer

This study identifies a biparatopic nanobody that protects mice from lethal SARS-CoV-2 infection and reduces viral load and inflammation.

bioRxiv · Aug 8, 2021 · PreprintBiochemistry

Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22

D. Schnepf, P. Hernandez, T. Mahlakoiv, S. Crotta, M. E. Sullender, S. T. Peterson, A. Ohnemus, C. Michiels, I. Gentle, L. Dumoutier, C. A. Reis, A. Diefenbach, A. Wack, M. T. Baldridge, P. Staeheli

This study shows that antibiotic-treated mice are more susceptible to rotavirus due to reduced IL-22 expression, which normally inhibits viral replication through mechanisms independent of IFN signaling.

bioRxiv · Feb 18, 2021Immunology