Author

A. Ohnemus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

D. Schnepf· 4 shared M. Schwemmle· 3 shared A. Wack· 2 shared J. Beer· 2 shared P. Staeheli· 2 shared S. Crotta· 2 shared A. Breithaupt· 1 shared A. Diefenbach· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersImmunology

D. Schnepf

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Author profile →

4 papers

Recent·Most cited

IFN-lambda is protective against lethal oral Toxoplasma gondii infection

M. Murillo-Leon, A. M. Bastidas-Quintero, N. S. Endres, D. Schnepf, E. Delgado-Betancourt, A. Ohnemus, G. A. Taylor, M. Schwemmle, P. Staeheli, T. Steinfeldt

This study shows that IFN-lambda protects against lethal oral Toxoplasma gondii infection by enhancing intestinal epithelial and neutrophil responses.

bioRxiv · Feb 24, 2023 · PreprintImmunology

Impaired immune response drives age-dependent severity of COVID-19

J. Beer, S. Crotta, A. Breithaupt, A. Ohnemus, J. Becker, B. Sachs, L. Kern, M. Llorian, N. Ebert, F. Labroussaa, T. T. N. Tran, B. S. Trueeb, J. Jores, V. Thiel, M. Beer, , D. Schnepf

This study identifies impaired interferon responses as a cause of age-dependent COVID-19 severity and shows that combined IFN-γ and IFN-λ therapy can mitigate disease in aged mice.

bioRxiv · Apr 21, 2022Immunology

A broadly neutralizing biparatopic Nanobody protects mice from lethal challenge with SARS-CoV-2 variants of concern

T. R. Wagner, D. Schnepf, J. Beer, K. Klingel, N. Ruetalo, P. D. Kaiser, D. Junker, M. Sauter, B. Traenkle, D. I. Frecot, M. Becker, N. Schneiderhan-Marra, A. Ohnemus, M. Schwemmle, M. Schindler, U. Rothbauer

This study identifies a biparatopic nanobody that protects mice from lethal SARS-CoV-2 infection and reduces viral load and inflammation.

bioRxiv · Aug 8, 2021 · PreprintBiochemistry

Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22

D. Schnepf, P. Hernandez, T. Mahlakoiv, S. Crotta, M. E. Sullender, S. T. Peterson, A. Ohnemus, C. Michiels, I. Gentle, L. Dumoutier, C. A. Reis, A. Diefenbach, A. Wack, M. T. Baldridge, P. Staeheli

This study shows that antibiotic-treated mice are more susceptible to rotavirus due to reduced IL-22 expression, which normally inhibits viral replication through mechanisms independent of IFN signaling.

bioRxiv · Feb 18, 2021Immunology