C. Murphy

P. aeruginosa controls both C. elegans attraction and pathogenesis by regulating nitrogen assimilation

This study identifies ammonia as a key mediator of trans-kingdom signaling between P. aeruginosa and C. elegans, showing how bacterial nitrogen assimilation affects both attraction and pathogenesis.

Defining metabolic flexibility in hair follicle stem cell induced squamous cell carcinoma

This study investigates metabolic flexibility in hair follicle stem cell-derived squamous cell carcinoma by blocking glycolysis and glutaminolysis, showing tumors can compensate by upregulating lactate consumption.

Extracellular vesicles, syntaxin 2 and SNAP23 collectively play a role in the receptive uterine microenvironment

The paper investigates the role of extracellular vesicles, syntaxin 2, and SNAP23 in uterine luminal fluid during uterine receptivity, showing their presence and potential role in creating a favorable microenvironment for blastocyst implantation.

Synthetic glycans that control gut microbiome structure mitigate colitis in mice

The paper describes synthetic glycans that alter gut microbiome structure and reduce colitis in mice by selectively affecting bacterial growth and metabolism.

Novel elasticity measurement techniques reveal that the C. elegans cuticle is required for physical integrity with age

The paper develops new elasticity measurement techniques to show that the C. elegans cuticle maintains physical integrity with age, and that collagen mutations and aging affect cuticle elasticity.

Genomes of novel Myxococcota reveal severely curtailed machineries for predation and cellular differentiation

This study analyzes genomes of novel Myxococcota from anaerobic habitats, revealing reduced capacities for predation and cellular differentiation compared to soil-dwelling relatives.

Microbial diversity and sulfur cycling in an early earth analogue: From ancient novelty to modern commonality

The paper examines microbial diversity and sulfur cycling in an anoxic spring, showing ancient microbial lineages and processes that reflect early Earth conditions and the impact of oxygenation.

High throughput identification of miR-145 targets in human articular chondrocytes

This study identifies miR-145 targets in human articular chondrocytes using RIP-seq and validation methods, showing it regulates genes involved in cartilage homeostasis and inflammation.

Lineage reversion drives WNT independence in intestinal cancer

This study identifies lineage reversion as a mechanism enabling WNT-independent growth in intestinal cancer by integrating genetic alterations and extracellular signals.

De Novo Growth Of Methanogenic Granules Indicates A Biofilm Life-Cycle With Complex Ecology

The paper investigates the life cycle of methanogenic granules by starting bioreactors with size-separated granules, showing new granule growth and identifying key microbial taxa shaping community structure.

Horizontal gene transfer as an indispensible driver for Neocallimastigomycota evolution into a distinct gut-dwelling fungal lineage

This paper identifies 283 horizontal gene transfer events in anaerobic gut fungi, showing HGT's role in their adaptation to the herbivorous gut environment.

Legionella pneumophila translocated translation inhibitors are required for bacterial-induced host cell cycle arrest

This study shows that Legionella pneumophila uses translation inhibitors to block host cell cycle progression and prevent entry into S phase, which is toxic for bacterial replication.