Author

S. Ganeshkumar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Graham· 1 shared A. Majumbar· 1 shared A. S. Cloud· 1 shared A. Yang· 1 shared D. A. Harki· 1 shared D. Rasmussen· 1 shared E. B. Faber· 1 shared E. Roberts· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperPhysiology

A. Graham

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Author profile →

2 papers

Recent·Most cited

Development of allosteric, selective cyclin-dependent kinase 2 (CDK2) inhibitors that are negatively cooperative with cyclin binding and show potential as contraceptive agents

E. B. Faber, J. Tang, E. Roberts, S. Ganeshkumar, L. Sun, N. Wang, D. Rasmussen, A. Majumbar, K. John, A. Yang, H. Khalid, J. E. Hawkinson, N. M. Levinson, E. Schonbrunn, V. Chennathukuzhi, , G. I. Georg

This paper develops high-affinity, structurally confirmed allosteric CDK2 inhibitors that show negative cooperativity with cyclin binding and demonstrate contraceptive potential in mouse testicular explants.

bioRxiv · Jun 30, 2022 · PreprintPharmacology & Toxicology

Loss of the repressor REST affects progesterone receptor function and promotes uterine leiomyoma pathogenesis

A. S. Cloud, M. M. McWilliams, F. Koohestani, S. Ganeshkumar, S. Gunewardena, A. Graham, W. B. Nothnick, V. M. Chennathukuzhi

This study shows that loss of REST in mouse uterus leads to uterine leiomyoma-like gene expression and altered progesterone receptor function, suggesting a mechanism for hormone-related tumor growth.

bioRxiv · Apr 11, 2022Physiology