S. Hansen

Design principles of small intestinal crypt maintenance

The paper develops a spatially and temporally resolved model of small intestinal crypt maintenance using integrated approaches, revealing CBC cells as the main driver of tissue replenishment.

JAK/STAT signaling promotes the emergence of unique cell states in ulcerative colitis

This study uses scRNA-seq to show JAK/STAT signaling creates unique regenerative cell states in ulcerative colitis, altering normal tissue replenishment patterns.

Multiple parallel expansions of bilaterian-like phototransduction gene families in the eyeless Anthozoa

The paper identifies bilaterian-like phototransduction gene families in the eyeless sea anemone Nematostella vectensis, suggesting ancestral phototransduction diversity in eumetazoans.

Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for co-receptor discrimination

The paper determines the structure of a ternary Wnt-Frizzled-LRP6 complex, revealing how co-receptor discrimination occurs through specific domains.

Hydroxychloroquine: mechanism of action inhibiting SARS-CoV2 entry.

This study investigates how hydroxychloroquine inhibits SARS-CoV-2 entry by disrupting lipid rafts and PIP2 domains that cluster the ACE2 receptor.

The role of high cholesterol in age related COVID19 lethality.

This study shows high cholesterol enhances SARS-CoV-2 entry and infectivity by promoting ACE2 and furin localization, contributing to COVID19 severity in elderly and obese individuals.

The Stone Age Plague: 1000 years of Persistence in Eurasia

This study identifies six new Yersinia pestis genomes from the European Late Neolithic to Bronze Age, suggesting a single genetic clade that may have persisted in Europe until the mid Bronze Age.