K. Jensen

Design principles of small intestinal crypt maintenance

The paper develops a spatially and temporally resolved model of small intestinal crypt maintenance using integrated approaches, revealing CBC cells as the main driver of tissue replenishment.

Soil organic carbon stocks and stabilization mechanisms in tidal marshes along estuarine gradients

This study examines SOC stocks and stabilization mechanisms in tidal marshes along estuarine gradients, finding that salinity and flooding reduce SOC storage and alter organic matter fractions.

Partitioning biota along the Elbe River estuary: where are the community transitions?

The paper examines community transitions in the Elbe River estuary, finding two distinct communities for plants and soil bacteria but not for aquatic microbes.

JAK/STAT signaling promotes the emergence of unique cell states in ulcerative colitis

This study uses scRNA-seq to show JAK/STAT signaling creates unique regenerative cell states in ulcerative colitis, altering normal tissue replenishment patterns.

Relationships of crystallinity and reaction rates for enzymatic degradation of poly (ethylene terephthalate), PET

The paper investigates how crystallinity affects enzymatic degradation of PET, finding that high crystallinity limits enzyme activity due to conformational constraints and reduces productive sites on the polymer surface.

Investigating the role of Mce proteins in Mycobacterium avium paratuberculosis infection

This study identifies Mce1A and Mce1D as effector molecules in MAP that enhance bacterial attachment and invasion in specific cell types.

Reaction pathways for the enzymatic degradation of poly(ethylene terephthalate): What characterizes an efficient PET-hydrolase?

The paper identifies endo-lytic activity as a key determinant of PET hydrolase efficiency by analyzing reaction pathways and enzyme kinetics.

Development of 3D bovine intestinal organoid derived models to investigate Mycobacterium avium ssp paratuberculosis pathogenesis

This study develops 3D bovine intestinal organoid models to study Mycobacterium avium ssp. paratuberculosis infection and finds that C49 is more invasive than K10 in these models.

Disease diagnostics using machine learning of immune receptors

The paper develops Mal-ID, a machine learning framework using immune receptor data to diagnose diseases, detecting infections, autoimmune disorders, and vaccine responses.

Sabatier principle for rationalizing enzymatic hydrolysis of a synthetic polyester

The paper applies the Sabatier principle to analyze PET hydrolase kinetics, showing that optimal turnover occurs at intermediate enzyme-PET binding strength, with implications for enzyme design and process optimization.

Comparative biochemistry of four polyester (PET) hydrolases

The paper compares four PET hydrolases using a kinetic framework to assess their efficiency and substrate affinity.

Nfkbid is required for immunity and antibody responses to Toxoplasma gondii

This study identifies Nfkbid as essential for immunity and antibody responses to Toxoplasma gondii, showing its role in B cell activation, B-1 cell development, and vaccine efficacy.

Physical constrains and functional plasticity of cellulases: Linear scaling relationships for a heterogeneous enzyme reaction

The paper characterizes 83 cellulases, revealing a linear free energy relationship between substrate binding strength and activation barrier, suggesting physical constraints and evolutionary optimization in interfacial enzyme catalysis.

Girls gone wild: Social isolation induces hyperactivity and exploration in aged female mice

This study examines the effects of late-life social isolation on aged female mice, finding increased hyperactivity and reduced anxiety-like behavior.

Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5

This study identifies NLRP3-dependent but inflammasome-independent pathways regulating CD8 T cell IFNγ responses to Toxoplasma gondii vacuolar antigens, independent of ROP5 virulence factors.

Adaptive laboratory evolution reveals general and specific chemical tolerance mechanisms and enhances biochemical production

This study uses adaptive laboratory evolution to identify chemical tolerance mechanisms in E. coli and shows how pre-tolerized strains can enhance biochemical production.

Cameo: A Python Library for Computer Aided Metabolic Engineering and Optimization of Cell Factories

Cameo provides an open-source Python platform for in silico design of cell factories, offering tools for metabolic engineering strategies and optimization.