D. Choi

Timing of treatment shapes the path to androgen receptor signaling inhibitor resistance in prostate cancer

This study shows that treatment timing affects the path to androgen receptor signaling inhibitor resistance in prostate cancer, with resistance arising through different mechanisms depending on the tumor context.

An RXLR effector targets ER-Golgi interface to induce ER stress and necrotic cell death

This study identifies Pc12, an RXLR effector from P. capsici, which induces necrotic cell death by disrupting ER-Golgi trafficking through interaction with Rab13-2.

The prevalence of Fusobacterium nucleatum subspecies in the oral cavity stratifies by local health status

This study investigates the prevalence of Fusobacterium nucleatum subspecies in the oral cavity and finds that their distribution varies with local health status.

An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies

This study curates a dataset of influenza HA antibodies and develops an explainable language model to predict antibody specificity, identifying and validating HA stem antibodies.

Population genomics of Aspergillus sojae is shaped by the food environment

This study examines how long-term use of Aspergillus sojae in soy fermentation shaped its population structure, genome variation, and phenotypic traits, revealing reduced genetic diversity and loss of aflatoxin production.

Remote neuronal activity drives glioma infiltration via Sema4f

This study identifies callosal projection neurons as drivers of glioma infiltration through Sema4F-mediated activity-dependent signaling in mouse and human tumors.

Oomycete effector AVRblb2 targets cyclic nucleotide-gated channels through calcium sensors to suppress pattern-triggered immunity

This study identifies AVRblb2 as an effector that targets CNGC channels via CaM/CML proteins to suppress PTI in plants.

Type 1 interferon perturbates clonal competition by reshaping human blood development

The paper investigates how type 1 interferon affects clonal competition in human blood development by altering HSC differentiation states and clonal fitness.

A Phytophthora nucleolar effector, Pi23226, targets to host ribosome biogenesis for necrotrophic cell death

This study identifies Pi23226, a Phytophthora effector that targets host ribosome biogenesis, inducing nucleolar stress and cell death to promote pathogenicity.

The Phytophthora capsici RxLR effector CRISIS2 has roles in suppression of PTI and triggering cell death in host plant

This study identifies CRISIS2, an RxLR effector from Phytophthora capsici, which suppresses plant immunity by interacting with PMA and BAK1, leading to cell death and enhanced pathogen virulence.

A merger between compatible but divergent genomes supports allopolyploidization in the Brassicaceae family

This study investigates how genome divergence and compatibility contribute to the stabilization of hybrid genomes in an allopolyploid plant species.

Bioactive Hydrogel Microcapsules for Guiding Stem Cell Fate Decisions by Release and Reloading of Growth Factors

This paper develops bioactive microcapsules to guide hPSC fate by releasing and reloading growth factors, reducing GF usage and improving differentiation outcomes.

Ex vivo therapeutic base and prime editing using chemically derived hepatic progenitors in a mouse model of tyrosinemia type 1

This study corrects a disease-causing mutation in a mouse model of tyrosinemia type 1 using ex vivo base and prime editing with chemically derived hepatic progenitors, improving survival rates.

Plant NLR targets P-type ATPase for executing plasma membrane depolarization leading to calcium influx and cell death

The paper shows that the plant NLR CCA309 targets P-type ATPase to cause membrane depolarization, calcium influx, and cell death during hypersensitive response.

Genome-wide functional analysis of hot pepper immune receptors reveals an autonomous NLR cluster in seed plants

This study identifies an autonomous NLR cluster in seed plants through functional analysis of hot pepper immune receptors, revealing conserved autoactive NLRs that trigger cell death independently of helper NLRs.

Olfactory ensheathing cells from the nasal mucosa and olfactory bulb have distinct membrane properties

This study compares membrane properties of olfactory ensheathing cells (OECs) from the nasal mucosa and olfactory bulb, finding distinct ion current behaviors between peripheral and central OECs.

Mechanotransduction-dependent control of stereocilia dimensions and row identity in inner hair cells

This study shows that mechanotransduction channels specify and maintain stereocilia row identity and control their diameter in inner hair cells.

Single-cell proteomics reveals downregulation of TMSB4X to drive actin release for stereocilia assembly

The paper uses single-cell proteomics to show TMSB4X downregulation drives actin release for stereocilia assembly in hair cells.

A human pathogenic bacterium Shigella proliferates in the plant through the adoption of type III effectors for Shigellosis

This study shows Shigella strains proliferate in Arabidopsis plants using type III effectors similar to their role in human infections.

GREB1 amplifies androgen receptor output in prostate cancer and contributes to antiandrogen resistance

This study identifies GREB1 as a driver of antiandrogen resistance in prostate cancer by amplifying androgen receptor output through enhanced DNA binding and p300 recruitment.

Multiple reference genome sequences of hot pepper reveal the massive evolution of plant disease resistance genes by retroduplication

The paper reports multiple pepper genomes and finds that retroduplication via LTR-retrotransposons drives expansion of disease resistance genes in plants.