D. Kmiec

Tetherin restricts SARS-CoV-2 replication despite antagonistic effects of Spike and ORF7a

This study shows that SARS-CoV-2 S and ORF7a antagonize Tetherin, but Tetherin still restricts SARS-CoV-2 replication.

A nuclear export signal in KHNYN required for its antiviral activity evolved as ZAP emerged in tetrapods

Regulation of KHNYN antiviral activity by the extended di-KH domain and nucleo-cytoplasmic trafficking

This paper identifies the extended di-KH and CUBAN domains in KHNYN as critical for its antiviral activity and interaction with ZAP, showing that the CUBAN domain regulates trafficking and abundance.

SARS-CoV-2 variants of concern are dependent on IFITM2 for efficient replication in human lung cells

The paper was withdrawn due to duplicate submission and is not intended for citation.

SARS-CoV-2 variants of concern remain dependent on IFITM2 for efficient replication in human lung cells

This study shows that SARS-CoV-2 variants of concern (VOCs) require IFITM2 for efficient replication in human lung cells, with IFITM2 depletion reducing viral RNA and infectious virus production by over four orders of magnitude.

The Delta variant of SARS-CoV-2 maintains high sensitivity to interferons in human lung cells

This study examines IFN sensitivity of SARS-CoV-2 variants, finding Delta remains as sensitive as early isolates, while Alpha, Beta, and Gamma show increased resistance.

The C-terminal PARP domain of the long ZAP isoform contributes essential effector functions for CpG-directed antiviral activity

This study identifies the C-terminal PARP domain and CaaX box of ZAP-L as essential for CpG-directed antiviral activity by modulating cofactor interactions and subcellular localization.

Species-specific differences in antagonism of APOBEC3 proteins by HIV-2 and SIVsmm Vif proteins

This study compares the ability of HIV-2 and SIVsmm Vif proteins to counteract human APOBEC3 proteins, showing HIV-2 acquired adaptive changes for efficient counteraction in humans.

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition

This study shows that IFITM proteins are required for SARS-CoV-2 infection and can be targeted to inhibit viral entry and replication.

The Zinc Finger Antiviral Protein restricts SARS-CoV-2

This paper identifies ZAP as an IFN-induced antiviral effector that restricts SARS-CoV-2 by targeting CpG dinucleotides, though SARS-CoV-2 may be adapted to low CpG environments.

Structural basis for tetherin antagonism as a barrier to zoonotic lentiviral transmission

The paper determines the structure of SIV Nef interacting with simian tetherin and AP-2, revealing how Nef bypasses tetherin's antiviral function by refolding AP-2 and creating a binding site for the DIWK motif.