C. Dunsby

Imaging of MAP kinase dynamics reveals endocytic regulation of pulsatile signalling and network re-wiring in response to targeted therapy in EGFR-mutant non-small cell lung cancer

The paper uses single-cell imaging to show that drug-tolerant cells in EGFR-mutant lung cancer rewired ERK signaling through endocytic pathways and adhesion complexes, driven by YAP and PTPRS.

Remote-refocusing light-sheet fluorescence microscopy enables 3D imaging of electromechanical coupling of hiPSC-derived and adult cardiomyocytes in co-culture

This study uses remote-refocusing light-sheet microscopy to image electromechanical coupling in co-cultured adult and hiPSC-derived cardiomyocytes, showing improved coupling over time.

Robust, single-shot, optical autofocus system utilizing cylindrical lenses to provide high precision and long range of operation

This paper introduces an optical autofocus system with high precision and long range for microscopy, demonstrating its use in multiwell plate imaging and single molecule localization microscopy.

Environmentally dependent and independent control of cell shape determination by Rho GTPase regulators in melanoma

This study compares cell shape determination in 2D and 3D environments using melanoma cells and identifies Rho GTPase regulators that modulate shape changes in response to environmental cues.

Single-shot phase contrast microscopy using polarisation-resolved differential phase contrast

The paper introduces a single-shot differential phase microscopy technique using a polarisation-sensitive camera to simultaneously acquire images for phase gradient and quantitative phase calculations.

Video-rate remote refocusing through continuous oscillation of a membrane deformable mirror.

This paper demonstrates a deformable mirror system for rapid refocusing in microscopy, achieving video-rate volumetric imaging with high Strehl metrics.

Robust optical autofocus system utilizing neural networks trained for extended range and time-course and automated multiwell plate imaging including single molecule localization microscopy

The paper develops a neural network-based autofocus system for microscopy, improving accuracy and range for long-term and multiwell plate imaging.

Dual-view oblique plane microscopy (dOPM)

This paper introduces a new dual-view oblique plane microscopy technique that improves resolution and reduces shadow artefacts in multi-cellular spheroid imaging.

Signal bias at glucagon family receptors: rationale and downstream impacts

The paper investigates signal bias at glucagon family receptors, showing biased agonists affect intracellular signaling and insulin secretion differently.

The influence of peptide context on signalling and trafficking of glucagon-like peptide-1 receptor biased agonists

The paper evaluates how peptide context affects GLP-1R signaling and trafficking, showing differences in agonist-mediated responses based on sequence homology and structural features.