S. Bailey

Imaging of MAP kinase dynamics reveals endocytic regulation of pulsatile signalling and network re-wiring in response to targeted therapy in EGFR-mutant non-small cell lung cancer

The paper uses single-cell imaging to show that drug-tolerant cells in EGFR-mutant lung cancer rewired ERK signaling through endocytic pathways and adhesion complexes, driven by YAP and PTPRS.

Integrating molecular and clinical variables to predict myocardial recovery

This study integrates clinical and transcriptomic data to predict myocardial recovery in heart failure patients after LVAD implantation, identifying 80 features with an AUC of 0.731.

Deep Learning Model Imputes Missing Stains in Multiplex Images

The paper introduces a deep learning model, MAXIM, to impute missing protein markers in multiplex images, improving efficiency in staining and imaging processes.

Deletion of 12-lipoxygenase normalizes platelet function after storage and transfusion in thrombocytopenic mice

This study shows that deleting 12-LOX improves post-transfusion function of stored murine platelets by altering fatty acid and oxylipin profiles.

Medulloblastoma Group 3 and 4 Tumors Comprise a Clinically and Biologically Significant Expression Continuum Reflecting Human Cerebellar Development

The paper shows medulloblastoma Group3 and Group4 tumors form a transcriptional continuum linked to cerebellar development, with prognostic and molecular implications.

Prediction of cancer treatment response from histopathology images through imputed transcriptomics

ENLIGHT-DeepPT predicts cancer treatment response from H&E slides by first imputing transcriptomics and then using that data to predict response across multiple therapies and cancer types.

Detection of velogenic avian paramyxoviruses in rock doves in New York City, New York

The paper screens wild birds in NYC for APMV-1, identifies two isolates, and classifies them into genotype VI, highlighting their potential role in NDV outbreaks.

Epigenetic regulator genes direct lineage switching in MLL-AF4 leukaemia

This study shows that lineage switching in MLL-AF4 leukaemia is driven by dysregulation of epigenetic regulators like NuRD, leading to reprogramming of gene regulatory networks from B lymphoid to myeloid.

The conserved zinc-finger protein GTSF1helps PIWI proteins achieve their full catalytic potential

This study identifies GTSF1 as an auxiliary protein that enhances the catalytic activity of PIWI proteins by potentiating their weak piRNA-directed RNA cleavage.

Cell-free DNA (cfDNA) and exosome profiling from a year-long humanspaceflight reveals circulating biomarkers

This study profiles cfDNA and exosomes from an astronaut during a year-long spaceflight, identifying increased cf-mtDNA and exosomal brain-derived peptides as potential biomarkers of spaceflight-related stress.

Single molecule analysis of effects of non-canonical guide RNAs and specificity-enhancing mutations on Cas9-induced DNA unwinding

The paper evaluates how non-canonical guide RNAs and Cas9 variants affect DNA unwinding, finding that some combinations reduce off-target activity while maintaining on-target efficiency.

The distribution of fitness effects among synonymous mutations in a gene under selection

The paper estimates the distribution of fitness effects among synonymous mutations in a gene under selection and finds they can be deleterious or beneficial, similar to nonsynonymous mutations.

Immune profiling of cord blood after prolonged rupture of membranes.

This study identifies transcriptomic changes in cord blood following prolonged rupture of membranes, suggesting immune responses to potential in utero infections.

Real-time observation of DNA target interrogation and product release by the RNA-guided endonuclease CRISPR Cpf1

This study characterizes the DNA interrogation and product release kinetics of three Cpf1 orthologues using single-molecule fluorescence and biochemical assays, revealing differences from Cas9 in binding and cleavage requirements.

Mechanisms of improved specificity of engineered Cas9s revealed by single molecule analysis

This study reveals how engineered Cas9 variants improve specificity by altering DNA unwinding dynamics and cleavage rates in response to mismatches.