Author

K. Valand

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:microscopy & imaging analysis· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Assay:imaging· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

J. Downward· 4 shared C. Moore· 3 shared C. Swanton· 3 shared E. Mugarza· 3 shared F. van Maldegem· 3 shared M. Cole· 3 shared S. Rana· 3 shared E. Colliver· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

J. Downward

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Imaging of MAP kinase dynamics reveals endocytic regulation of pulsatile signalling and network re-wiring in response to targeted therapy in EGFR-mutant non-small cell lung cancer

A. M. I. Le Marois, S. Bailey, S. Hooper, S. Kumar, H. Sparks, Y. Alexandrov, D. R. Caswell, F. Fröhlich, K. Schlegelmilch, K. Valand, M. J. Martin, A. J. Narvaez, C. Swanton, J. Downward, C. Dunsby, , E. Sahai

The paper uses single-cell imaging to show that drug-tolerant cells in EGFR-mutant lung cancer rewired ERK signaling through endocytic pathways and adhesion complexes, driven by YAP and PTPRS.

bioRxiv · May 14, 2024 · PreprintCancer Biology

Spatial proteomic analysis of a lung cancer model reveals regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses

M. Cole, P. Anastasiou, C. Lee, C. Moore, E. Mugarza, M. Jones, K. Valand, S. Rana, E. Colliver, M. Angelova, K. Enfield, A. Magness, A. Mullokandov, G. Kelly, T. de Gruijl, , F. van Maldegem

The paper identifies regulatory T cells as mediators of resistance to KRAS-G12C inhibitors and anti-PD-1 therapy through spatial proteomic analysis of lung cancer models.

bioRxiv · Apr 11, 2024Cancer Biology

Therapeutic KRASG12C inhibition drives effective interferon-mediated anti-tumour immunity in immunogenic lung cancers

E. Mugarza, F. van Maldegem, J. Boumelha, C. Moore, S. Rana, M. L. Sopena, P. East, R. Ambler, P. Anastasiou, P. R. Clavijo, K. Valand, M. Cole, M. Molina-Arcas, J. Downward

KRASG12C inhibition enhances anti-tumour immunity in immunogenic lung cancers by upregulating interferon signaling through Myc repression, but only synergizes with immune checkpoint blockade in highly immunogenic models.

bioRxiv · Oct 18, 2021Cancer Biology

Characterisation of tumour immune microenvironment remodelling following oncogene inhibition in preclinical studies using an optimised imaging mass cytometry workflow

F. van Maldegem, K. Valand, M. Cole, H. Patel, M. Angelova, S. Rana, E. Colliver, K. Enfield, N. Bah, V. Tsang, E. Mugarza, C. Moore, P. Hobson, D. Levi, M. Molina, , J. Downward

The paper optimises an imaging mass cytometry workflow to study TME remodelling in mouse models after KRAS G12C inhibitor treatment.

bioRxiv · Feb 2, 2021Cancer Biology