S. Humphries

Hypomethylating agents induce epigenetic and transcriptional heterogeneity with implications for AML cell self-renewal.

This study shows that hypomethylating agents induce epigenetic and transcriptional heterogeneity in AML cells, with some cells retaining methylation and showing increased self-renewal, and identifies statins as a potential co-treatment to enhance HMA efficacy.

Hypoxia alters the effects of hypomethylating agents in acute myeloid leukaemia cells.

This study shows hypoxia reduces the effectiveness of hypomethylating agents in AML cells by altering DNA methylation and antigen presentation pathways.

Optimal cell length for exploration and exploitation in chemotactic planktonic bacteria

This study investigates the optimal cell length for chemotaxis in bacteria, finding that intermediate lengths balance exploration and exploitation of nutrient sources.

150 million years of sustained increase in pterosaur flight efficiency

This study investigates the evolutionary increase in pterosaur flight efficiency over 150 million years, focusing on changes in locomotion energetics.

Phenotypic reconstruction of the last universal common ancestor reveals a complex cell

This study reconstructs the phenotype of the last universal common ancestor (LUCA) using ancestral character reconstruction, finding it to be a complex prokaryotic cell with a cell wall, motility, and thermophilic traits.

Microrheology reveals microscale viscosity gradients in planktonic systems

The paper uses microrheology to measure microscale viscosity gradients around phytoplankton cells and within aggregates, revealing heterogeneous viscosity that affects chemical and microbial distribution.

Estimation of sinking velocities using free-falling dynamically scaled models: foraminifera as a test case

The paper develops a method to estimate sinking velocities of microscale particles using 3D printed scale models, validated with foraminifera as a test case.

Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274

The paper identifies metabolic dysregulation of lysophospholipid/autotaxin pathways linked to a CHD risk SNP, showing altered lipid metabolism and enzyme expression in multiple models.

Motile curved bacteria are Pareto-optimal

The paper uses in silico experiments to show that curved bacterial shapes are Pareto-optimal, balancing swimming efficiency, chemotaxis, and cell construction cost.