Author

A. Kovaltsuk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 8

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 7 Organism:human· 6 Approach:experimental assay· 4 Organism:mouse· 3 Assay:scRNA-seq· 3 Research Focus:database / resource· 2 Approach:deep learning· 2 Assay:proteomics· 2

Frequent Co-Authors

C. M. Deane· 7 shared J. D. Galson· 4 shared M. I. J. Raybould· 4 shared C. Marks· 3 shared J. Trück· 3 shared M. Ghraichy· 3 shared D. F. Kelly· 2 shared J. Snowden· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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7 shared papersImmunology

C. M. Deane

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8 papers

Recent·Most cited

Characterisation of the immune repertoire of a humanised transgenic mouse through immunophenotyping and high-throughput sequencing

E. Richardson, S. Binter, M. Kosmac, M. Ghraichy, V. von Niederhäusern, A. Kovaltsuk, J. D. Galson, J. Trück, D. F. Kelly, C. M. Deane, P. Kellam, S. Watson

The paper characterizes the immune repertoire of a humanised transgenic mouse using immunophenotyping and high-throughput sequencing, showing similarities to human BCR repertoires.

bioRxiv · Jun 27, 2022Immunology

Different B cell subpopulations show distinct patterns in their IgH repertoire metrics

M. Ghraichy, V. von Niederhäusern, A. Kovaltsuk, J. D. Galson, C. M. Deane, J. Trück

The paper compares IgH repertoire metrics across different B cell subpopulations and finds distinct patterns associated with their developmental stages and constant region positions.

bioRxiv · Sep 1, 2021Immunology

Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signatures

J. D. Galson, S. Schaetzle, R. J. M. Bashford-Rogers, M. I. J. Raybould, A. Kovaltsuk, G. J. Kilpatrick, R. Minter, D. K. Finch, J. Dias, L. James, G. Thomas, W.-Y. J. Lee, J. Betley, O. Cavlan, A. Leech, , J. Osbourn

The paper analyzes B cell receptor repertoires from COVID-19 patients to identify convergent immune signatures associated with disease outcome.

bioRxiv · May 20, 2020Immunology

CoV-AbDab: the Coronavirus Antibody Database

M. I. J. Raybould, A. Kovaltsuk, C. Marks, C. M. Deane

The paper introduces CoV-AbDab, a database of antibodies against SARS-CoV-2 and related betacoronaviruses, providing metadata and analysis tools for research applications.

bioRxiv · May 15, 2020Immunology

Evidence of Antibody Repertoire Functional Convergence through Public Baseline and Shared Response Structures

M. I. J. Raybould, C. Marks, A. Kovaltsuk, A. P. Lewis, J. Shi, C. Deane

The paper investigates functional convergence in human antibody repertoires by analyzing structural commonality in baseline and response antibodies, finding high structural similarity across individuals.

bioRxiv · Mar 17, 2020Immunology

Maturation of the human B-cell receptor repertoire with age

M. Ghraichy, J. D. Galson, A. Kovaltsuk, V. von Niederhaeusern, J. Pachlopnik Schmid, M. Recher, A. Jauch, E. Miho, D. F. Kelly, C. M. Deane, J. Trueck

This study examines age-related changes in human B-cell receptor repertoires, finding significant shifts in immunoglobulin gene usage and self-reactive antibody frequencies during early life and aging.

bioRxiv · Dec 20, 2019 · PreprintImmunology

Structural Diversity of B-Cell Receptor Repertoires along the B-cell Differentiation Axis in Humans and Mice

A. Kovaltsuk, M. I. J. Raybould, W. K. Wong, C. Marks, S. Kelm, J. Snowden, J. Trück, C. M. Deane

The paper structurally characterizes B-cell receptor paratopes in humans and mice, showing structural differences across B-cell differentiation stages and conservation in naive repertoires.

bioRxiv · Sep 9, 2019Immunology

Observed Antibody Space: a resource for data mining next generation sequencing of antibody repertoires

A. Kovaltsuk, J. Leem, S. Kelm, J. Snowden, C. M. Deane, K. Krawczyk

The paper introduces a resource called Observed Antibody Space (OAS) that curates and provides access to over half a billion antibody sequences from 53 studies for immune repertoire analysis.

bioRxiv · May 19, 2018Immunology