S. Kobayashi

Stereoinversion via alcohol dehydrogenases enables complete catabolism of β-1-type lignin-derived aromatic isomers

This paper identifies the catabolic pathway for threo-DGPD in SYK-6, showing it is converted to erythro-DGPD via oxidation and reduction by multiple dehydrogenases, enabling complete catabolism of all four β-1-type lignin-derived isomers.

Structure of the human Bre1 complex bound to the nucleosome

The paper determines the cryo-EM structure of the human Bre1 complex bound to the nucleosome, revealing how it catalyzes H2B monoubiquitination and its potential role in cancer.

Inhibitory effect of Ephedra herba on human norovirus infection in human intestinal organoids

This study screens Kampo crude drugs for anti-HuNoV effects using human intestinal organoids, identifying Ephedra herba as a novel inhibitor targeting the post-entry step of infection.

Morphogenesis of bullet-shaped rabies virus particles requires a functional interplay between the viral matrix protein and ESCRT-I component TSG101

This study identifies the interaction between rabies virus matrix protein and TSG101 as essential for bullet-shaped virion formation and efficient budding.

Enterococcal linear plasmids adapt to Enterococcus faecium and spread within multidrug-resistant clades.

This study identifies enterococcal linear plasmids that spread AMR genes through horizontal transfer and contribute to multidrug resistance in Enterococcus faecium.

Deep learning-based approach for the characterization and quantification of histopathology in mouse models of colitis

This paper trains a deep learning model to detect involved and uninvolved regions in H&E-stained colonic tissues of mouse colitis models to improve histopathological analysis.

Ameliorative effect of a quinazoline-based bromodomain inhibitor, CN210, on experimentally-induced Crohn's disease-like murine ileitis via inhibition of inflammatory cytokine expression

This study shows that CN210, a quinazoline-based BET inhibitor, reduces inflammation in a murine model of Crohn's disease by inhibiting inflammatory cytokine expression and NF-κB/MAP kinase pathways.

A biomimetic five-module chimeric antigen receptor (5MCAR) designed to target and eliminate antigen-specific T cells

This paper designs a biomimetic 5MCAR to target and eliminate antigen-specific T cells, showing it can mitigate type I diabetes in NOD mice.