S. Kondo

Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis in Drosophila

This paper characterizes the ITP signaling system in Drosophila, identifying ITPa as an anti-diuretic hormone that acts via the Gyc76C receptor to modulate osmoregulation and metabolic homeostasis.

In Vivo Imaging of Bone Collagen Dynamics in zebrafish

This study uses in vivo imaging in zebrafish to observe bone collagen dynamics and osteoblast interactions, revealing differences in collagen orientation based on promoter-specific osteoblast subpopulations.

Visual adaptation of opsin gene expression to the aquatic environment in sea turtles

This study compares opsin gene expression and evolution between marine and freshwater turtles, finding increased blue-sensitive opsin expression in marine species.

A humoral stress response protects Drosophila tissues from antimicrobial peptides

This study identifies Turandot stress proteins that protect Drosophila tissues from antimicrobial peptide-induced damage by binding phosphatidylserine and inhibiting AMP pore formation.

Coronin-1 controls directional cell rearrangement in Drosophila wing epithelium

This study shows Coronin-1 promotes directional cell rearrangement in Drosophila pupal wing by interacting with AIP1, affecting cell shape and tissue deformation.

Tackling Mitosis Domain Generalization in Histopathology Images with Color Normalization

The paper proposes a method for mitosis detection in histopathology images using color normalization and object detection, achieving an F1 score of 0.716 on a test set.

Female reproductive dormancy in Drosophila melanogaster is regulated by DH31-producing neurons projecting into the corpus allatum

This study identifies DH31-producing neurons projecting to the corpus allatum as essential for regulating reproductive dormancy in Drosophila by suppressing juvenile hormone biosynthesis.

Drosophila immunity: The Drosocin gene encodes two host defence peptides with pathogen-specific roles

This study identifies two host defence peptides encoded by the Drosocin locus in Drosophila, each with specific roles against different pathogens, and shows how a polymorphism affects susceptibility.

CCN2 activates ERK-signaling via integrin αv and enhances the interaction of ERK and DUSP6 in lymphatic endothelial cells

This study shows CCN2 promotes lymphangiogenesis by activating ERK signaling through integrin αv and enhancing ERK-DUSP6 interaction in lymphatic endothelial cells.

The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in Drosophila melanogaster

This study identifies Neuropeptide F (NPF) in Drosophila as a sugar-responsive incretin-like hormone that regulates lipid metabolism via glucagon-like and insulin-like hormones.

Drosophila antimicrobial peptides and lysozymes regulate gut microbiota composition and abundance

This study shows that antimicrobial peptides and lysozymes in Drosophila regulate gut microbiota composition and abundance, with their effects exacerbated during aging.

A population of neurons that produce hugin and express the diuretic hormone 44 receptor gene projects to the corpora allata in Drosophila melanogaster

This study identifies hugin-producing neurons that project to the corpora allata in Drosophila melanogaster and express the Dh44 receptor gene, revealing a neuronal pathway involved in JH regulation.

Evolutionary trajectories of three independent neo-sex chromosomes in Drosophila

The paper compares the evolutionary patterns of neo-sex chromosomes in three Drosophila species, finding accelerated pseudogenization and shared functional constraints across neo-X and neo-Y chromosomes.

Metabolic adjustment of Drosophila hemocyte number and sessility by an adipokine

This study identifies NimB5 as an adipokine that regulates hemocyte number and sessility in Drosophila larvae based on nutritional state.

The antimicrobial peptide Defensin cooperates with Tumour Necrosis Factor to drive tumour cell death in Drosophila

This study shows Defensin, an antimicrobial peptide, works with Tumour Necrosis Factor to kill tumour cells in Drosophila, demonstrating an in vivo anti-cancer role for an endogenous AMP.

ABC transporters confer multidrug resistance to Drosophila intestinal stem cells

This study shows that Drosophila intestinal stem cells exhibit multidrug resistance via ABC transporters, a feature conserved from vertebrates.

Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach

This study uses CRISPR to knockout Drosophila AMPs and shows they act synergistically or additively against Gram-negative bacteria and fungi, with specific AMPs targeting specific pathogens.

More than black and white: complex relationships involving serine proteases regulate the Toll pathway and the melanization response in Drosophila

This study identifies two distinct serine protease pathways regulating melanization and Toll signaling in Drosophila, revealing previously hidden roles of Hayan and Sp7.