Author

S. L. Londrigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:long-read sequencing· 2 Organism:Arabidopsis· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

F. L. Mordant· 3 shared K. Subbarao· 3 shared C. Zhou· 2 shared D. Rawlinson· 2 shared J. Gleeson· 2 shared L. J. M. Coin· 2 shared M. B. Clark· 2 shared M. E. Pitt· 2 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

F. L. Mordant

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Author profile →

3 papers

Recent·Most cited

Macrophages only sense infectious SARS-CoV-2 when they express sufficient ACE2 to permit viral entry, where rapid cytokine responses then limit viral replication.

L. I. Labzin, K. Y. Chew, K. Eschke, X. Wang, T. Esposito, C. J. Stocks, J. Rae, R. Patrick, H. Mostafavi, B. Hill, T. Yordanov, C. L. Holley, S. Emming, S. Fritzlar, F. L. Mordant, , K. Schroder

The paper shows that ACE2-expressing macrophages allow SARS-CoV-2 entry and replication, triggering anti-viral responses, while ACE2-negative macrophages do not support viral entry or cytokine release.

bioRxiv · Mar 22, 2022 · PreprintImmunology

Long-read RNA sequencing identifies polyadenylation elongation and differential transcript usage of host transcripts during SARS-CoV-2 in vitro infection

J. J.-Y. Chang, J. Gleeson, D. Rawlinson, M. E. Pitt, R. De Paoli-Iseppi, C. Zhou, F. L. Mordant, S. L. Londrigan, M. B. Clark, K. Subbarao, T. P. Stinear, L. J. M. Coin

The paper uses long-read RNA sequencing to study polyadenylation and transcript usage changes in host cells during SARS-CoV-2 infection, identifying differential polyadenylation and transcript usage in infected cells.

bioRxiv · Dec 14, 2021Immunology

Transcriptional and epi-transcriptional dynamics of SARS-CoV-2 during cellular infection

J. J.- Y. Chang, D. Rawlinson, M. E. Pitt, G. Taiaroa, J. Gleeson, C. Zhou, F. L. Mordant, R. De Paoli-Iseppi, L. Caly, D. F. J. Purcell, T. P. Stinear, S. L. Londrigan, M. B. Clark, D. A. Williamson, K. Subbarao, L. J. M. Coin

This study examines SARS-CoV-2 transcriptional and epi-transcriptional dynamics using long-read sequencing in human and primate infection models, revealing distinct patterns of sgRNA regulation and modification.

bioRxiv · Dec 22, 2020Microbiology