Regulation of heterotopic ossification through local inflammatory monocytes in a mouse model of aberrant wound healing
A. K. Huber, M. Sorkin, C. Hwang, W. F. Carson, R. Menon, J. Li, K. Vasquez, C. Pagani, N. Patel, S. Li, N. Visser, Y. Niknafs, S. Loder, M. Scola, D. Nycz, , B. Levi
This study identifies TGFβ1-producing monocytes/macrophages as drivers of heterotopic ossification in a mouse model and shows CD47 activation can reduce HO by modulating these cells.
bioRxiv · Dec 11, 2019 · PreprintImmunology