TrkA+ sensory neurons regulate osteosarcoma proliferation and vascularization to promote disease progression
A. W. James, Q. Qin, S. Ramesh, Z. Li, L. Zhong, M. Cherief, M. Archer, X. Xing, N. Thottappillil, M. Gomez-Salazar, M. Zhu, L. Chang, A. Uniyal, K. Mazhar, M. Mittal, , T. J. Price
This study shows that TrkA+ sensory neurons promote osteosarcoma progression by enhancing tumor growth, vascularization, and metastasis, and that inhibiting these neurons reduces disease severity and improves survival.
bioRxiv · Jun 20, 2024Cancer Biology