Author

S. Lun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Assay:metabolomics· 1

Frequent Co-Authors

I. Kramnik· 2 shared J. R. Murphy· 2 shared S. Parveen· 2 shared S. Xiao· 2 shared W. Bishai· 2 shared W. R. Bishai· 2 shared A. A. Ordonez· 1 shared A. Ivanov· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

I. Kramnik

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis

S. Parveen, J. Shen, S. Lun, L. Zhao, B. Koleske, R. D. Leone, R. Rais, J. D. Powell, J. R. Murphy, B. S. Slusher, W. R. Bishai

This study shows that JHU083, a glutamine metabolism inhibitor, reduces Mtb growth and modulates host immunity in tuberculosis, with effects dependent on host factors.

bioRxiv · Feb 23, 2023 · PreprintMicrobiology

Adjunctive inhibition of the integrated stress response pathway accelerates bacterial clearance in a mouse model of tuberculosis

S. Krug, P. Prasad, S. Xiao, S. Lun, C. A. Ruiz-Bedoya, M. Klunk, A. A. Ordonez, S. K. Jain, G. Srikrishna, I. Kramnik, W. Bishai

This study shows that inhibiting the Integrated Stress Response (ISR) pathway alongside standard TB antibiotics reduces bacterial loads and accelerates sterilization in a mouse model of tuberculosis.

bioRxiv · Dec 31, 2021 · PreprintMicrobiology

Effective host-directed therapy for tuberculosis by targeted depletion of myeloid-derived suppressor cells using a diphtheria toxin-based fusion protein

S. Parveen, S. Lun, M. E. Urbanowski, M. Cardin, J. R. Murphy, W. R. Bishai

This study shows that depleting myeloid-derived suppressor cells (MDSCs) using a diphtheria toxin-based fusion protein reduces Mycobacterium tuberculosis burden in mice.

bioRxiv · Dec 10, 2020Microbiology

The integrated stress response mediates type I interferon driven necrosis in Mycobacterium tuberculosis granulomas

B. Bhattacharya, S. Xiao, S. Chatterjee, M. Urbanowski, A. Ordonez, E. A. Ihms, G. Agrahari, S. Lun, R. Berland, A. Pichugin, Y. Gao, J. Connor, A. Ivanov, B.-S. Yan, L. Kobzik, , I. Kramnik

This study identifies the integrated stress response (ISR) as a mediator of necrosis in tuberculosis granulomas, showing that ISR inhibition reduces bacterial burden and necrosis in susceptible mice.

bioRxiv · Dec 19, 2018 · PreprintImmunology