Author

S. Mannepalli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Organism:Drosophila· 1

Frequent Co-Authors

L. Shapiro· 4 shared B. Honig· 3 shared F. Bahna· 3 shared P. S. Katsamba· 3 shared A. P. Sergeeva· 2 shared G. Ahlsen· 2 shared B. Zhang· 1 shared D. D. Ho· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersBiophysics

L. Shapiro

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4 papers

Recent·Most cited

Free energy perturbation calculations of mutation effects on SARS-CoV-2 RBD::ACE2 binding affinity

A. P. Sergeeva, P. S. Katsamba, J. M. Sampson, F. Bahna, S. Mannepalli, N. C. Morano, L. Shapiro, R. A. Friesner, B. Honig

This study uses free energy perturbation calculations to assess how mutations in SARS-CoV-2 RBD affect binding affinity to ACE2, showing FEP's superior accuracy in identifying stabilizing mutations.

bioRxiv · Aug 1, 2022Biophysics

How clustered protocadherin binding specificity is tuned for neuronal self/non-self-recognition

K. M. Goodman, P. S. Katsamba, R. Rubinstein, G. Ahlsen, F. Bahna, S. Mannepalli, H. Dan, R. Sampogna, L. Shapiro, B. Honig

This study investigates cPcdh interactions, showing promiscuous cis dimers and precise trans homophilic interactions, supporting their role in neuronal self/non-self-recognition.

bioRxiv · Jul 22, 2021Biophysics

Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class

M. Rapp, Y. Guo, E. R. Reddem, L. Liu, P. Wang, J. Yu, G. Cerutti, J. Bimela, F. Bahna, S. Mannepalli, B. Zhang, P. D. Kwong, D. D. Ho, L. Shapiro, Z. Sheng

The paper determines structures of three VH1-2-derived antibodies in complex with SARS-CoV-2 spike, revealing modular recognition mechanisms and conformational changes.

bioRxiv · Jan 11, 2021Immunology

DIP/Dpr interactions and the evolutionary design of specificity in protein families

A. P. Sergeeva, P. S. Katsamba, F. Cosmanescu, J. J. Brewer, G. Ahlsen, S. Mannepalli, L. Shapiro, B. Honig

The paper investigates how specificity in DIP/Dpr protein interactions is achieved through negative constraints, using computational and experimental methods.

bioRxiv · Jan 13, 2020Biophysics