Author

F. Bahna

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Assay:structural biology· 4 Organism:virus· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

L. Shapiro· 6 shared D. D. Ho· 4 shared E. R. Reddem· 4 shared G. Cerutti· 4 shared J. Yu· 4 shared P. D. Kwong· 4 shared P. S. Katsamba· 4 shared P. Wang· 4 shared

Activity by Year

2021-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

6 shared papersBiophysics

L. Shapiro

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Free energy perturbation calculations of mutation effects on SARS-CoV-2 RBD::ACE2 binding affinity

A. P. Sergeeva, P. S. Katsamba, J. M. Sampson, F. Bahna, S. Mannepalli, N. C. Morano, L. Shapiro, R. A. Friesner, B. Honig

This study uses free energy perturbation calculations to assess how mutations in SARS-CoV-2 RBD affect binding affinity to ACE2, showing FEP's superior accuracy in identifying stabilizing mutations.

bioRxiv · Aug 1, 2022Biophysics

How clustered protocadherin binding specificity is tuned for neuronal self/non-self-recognition

K. M. Goodman, P. S. Katsamba, R. Rubinstein, G. Ahlsen, F. Bahna, S. Mannepalli, H. Dan, R. Sampogna, L. Shapiro, B. Honig

This study investigates cPcdh interactions, showing promiscuous cis dimers and precise trans homophilic interactions, supporting their role in neuronal self/non-self-recognition.

bioRxiv · Jul 22, 2021Biophysics

Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain

G. Cerutti, Y. Guo, P. Wang, M. S. Nair, Y. Huang, J. Yu, L. Liu, P. S. Katsamba, F. Bahna, E. R. Reddem, P. D. Kwong, D. D. Ho, Z. Sheng, L. Shapiro

This paper reports the cryo-EM structure of antibody 5-7, which binds to a distinct site in the SARS-CoV-2 spike NTD, showing neutralization resistance to variants of concern.

bioRxiv · Jun 29, 2021Immunology

Structural Basis for Accommodation of Emerging B.1.351 and B.1.1.7 Variants by Two Potent SARS-CoV-2 Neutralizing Antibodies

G. Cerutti, M. Rapp, Y. Guo, F. Bahna, J. Bimela, E. R. Reddem, J. Yu, P. Wang, L. Liu, Y. Huang, D. D. Ho, P. D. Kwong, Z. Sheng, L. Shapiro

This study reports cryo-EM structures of two SARS-CoV-2 neutralizing antibodies bound to spike proteins of emerging variants, showing they retain potency despite RBD mutations.

bioRxiv · Feb 21, 2021Biochemistry

Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class

M. Rapp, Y. Guo, E. R. Reddem, L. Liu, P. Wang, J. Yu, G. Cerutti, J. Bimela, F. Bahna, S. Mannepalli, B. Zhang, P. D. Kwong, D. D. Ho, L. Shapiro, Z. Sheng

The paper determines structures of three VH1-2-derived antibodies in complex with SARS-CoV-2 spike, revealing modular recognition mechanisms and conformational changes.

bioRxiv · Jan 11, 2021Immunology

Potent SARS-CoV-2 Neutralizing Antibodies Directed Against Spike N-Terminal Domain Target a Single Supersite

G. Cerutti, Y. Guo, T. Zhou, J. Gorman, M. Lee, M. Rapp, E. R. Reddem, J. Yu, F. Bahna, J. Bimela, Y. Huang, P. S. Katsamba, L. Lihong, M. S. Nair, R. Rawi, , L. Shapiro

This study identifies potent SARS-CoV-2 neutralizing antibodies targeting the N-terminal domain (NTD) and reveals they bind a common supersite on the spike protein.

bioRxiv · Jan 10, 2021Biochemistry