Author

W. Chu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:mouse· 1

Frequent Co-Authors

B. D. Moore· 1 shared B. Kim· 1 shared B. Zhang· 1 shared C. BONNARD· 1 shared C. K. LIM· 1 shared C. L. Cummings· 1 shared C. M. Rudin· 1 shared C. R. HARAPAS· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperBioengineering

B. D. Moore

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Peptide ligands for the affinity purification of adeno-associated viruses from HEK 293 cell lysates

W. Chu, E. Barbieri, R. Prodromou, P. Greback-Clarke, W. K. Smith, B. D. Moore, R. E. Kilgore, C. L. Cummings, J. Pancorbo, G. L. Gilleskie, M. A. Daniele, S. Menegatti

The paper develops peptide-based adsorbents to purify AAV2 from HEK 293 cell lysates, achieving high recovery and reduced host proteins with comparable transduction activity to commercial methods.

bioRxiv · Feb 19, 2023Bioengineering

Actin dysregulation induces neuroendocrine plasticity and immune evasion: a vulnerability of small cell lung cancer

Y. Seo, S. Zhang, J. Jang, K.-P. Ko, K.-B. Kim, Y. Huang, D.-W. Kim, B. Kim, G. Zou, J. Zhang, S. Jun, W. Chu, N. A. Kirk, Y. E. Hwang, Y. H. Ban, , J.-I. Park

This study shows that CRACD, an actin regulator, suppresses neuroendocrine plasticity and immune evasion in SCLC by modulating NOTCH1 and EZH2 pathways, suggesting EZH2 blockade as a potential therapy.

bioRxiv · Feb 15, 2023Cancer Biology

Human NLRP1 is activated by ZAKa-driven ribotoxic stress response

K. S. ROBINSON, G. A. TOH, P. ROZARIO, S. BAYAT, Z. SUN, S. BAUERNFRIED, R. NADKARNI, C. R. HARAPAS, C. K. LIM, W. CHU, K. Y. TAN, C. BONNARD, R. SOBOTA, J. E. CONNOLLY, S. L. MASTERS, , F. L. Zhong

This paper identifies ZAKa-driven ribotoxic stress as a mechanism for activating human NLRP1, leading to pyroptosis in response to UVB and microbial ribotoxins.

bioRxiv · Jan 24, 2022 · PreprintImmunology

ACE2-Targeting Monoclonal Antibody as Potent and Broad-Spectrum Coronavirus Blocker

Y. Chen, Y. Zhang, R. Yan, G. Wang, Y. Zhang, Z. Zhang, Y. Li, j. ou, W. Chu, Z. Liang, y. wang, Y. Chen, G. Chen, Q. Wang, Q. Zhou, , C. Wang

This paper reports a monoclonal antibody, 3E8, that blocks multiple coronaviruses by targeting ACE2, showing broad-spectrum activity against SARS-CoV-2 variants and other coronaviruses.

bioRxiv · Nov 11, 2020Microbiology