PhysiologybioRxiv
Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury
DOI 10.1126/sciadv.abo2794
Author
S. N. Chaudhari
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2019-2021 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 23 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship4 papers
Recent·Most cited
- BiochemistrybioRxiv
A gut-restricted lithocholic acid analog as an inhibitor of gut bacterial bile salt hydrolases
A. A. Adhikari, D. Ramachandran, S. N. Chaudhari…·A. S. Devlin
The paper develops a gut-restricted BSH inhibitor, AAA-10, which effectively reduces secondary bile acids in mice with minimal systemic exposure.
DOI 10.1021/acschembio.1c00192 - BiochemistrybioRxiv
Bariatric surgery reveals a gut-restricted TGR5 agonist that exhibits anti-diabetic effects
S. N. Chaudhari, D. A. Harris, H. Aliakbarian…·A. S. Devlin
This study identifies CA7S, a gut-restricted TGR5 agonist that improves glucose tolerance in insulin-resistant mice by inducing GLP-1 secretion.
- MicrobiologybioRxiv
Development of a Covalent Inhibitor of Gut Bacterial Bile Salt Hydrolases
A. A. Adhikari, T. C. Seegar, S. B. Ficarro…·A. S. Devlin
This study develops a covalent inhibitor of gut bacterial bile salt hydrolases, showing it reduces BSH activity and deconjugated bile acids in mice.
DOI 10.1038/s41589-020-0467-3