Author

A. S. Devlin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 2 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:metabolomics· 2 Assay:metagenomics· 2 Assay:proteomics· 2

Frequent Co-Authors

S. N. Chaudhari· 4 shared A. A. Adhikari· 3 shared L. Yao· 3 shared M. D. McCurry· 3 shared A. S. Banks· 2 shared C. Huttenhower· 2 shared D. Ramachandran· 2 shared E. A. Franzosa· 2 shared

Activity by Year

2019-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersBiochemistry

S. N. Chaudhari

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury

D. K. Li, S. N. Chaudhari, M. Sojoodi, Y. Li, A. A. Adhikari, L. Zukerberg, S. Shroff, S. C. Barrett, K. Tanabe, R. T. Chung, A. S. Devlin

bioRxiv · Mar 24, 2021Physiology

A gut-restricted lithocholic acid analog as an inhibitor of gut bacterial bile salt hydrolases

A. A. Adhikari, D. Ramachandran, S. N. Chaudhari, C. E. Powell, M. D. McCurry, A. S. Banks, A. S. Devlin

The paper develops a gut-restricted BSH inhibitor, AAA-10, which effectively reduces secondary bile acids in mice with minimal systemic exposure.

bioRxiv · Mar 15, 2021Biochemistry

Human gut bacteria produce TH17-modulating bile acid metabolites

D. Paik, L. Yao, Y. Zhang, S. Bae, G. D. D'Agostino, E. Kim, E. A. Franzosa, J. Avila-Pacheco, J. E. Bisanz, C. K. Rakowski, H. Vlamakis, R. J. Xavier, P. J. Turnbaugh, R. S. Longman, M. R. Krout, , A. S. Devlin

This study identifies human gut bacteria that produce TH17-modulating bile acid metabolites, showing reduced levels in IBD patients.

bioRxiv · Jan 8, 2021 · PreprintImmunology

A Bacterial Bile Acid Metabolite Modulates Treg Activity through the Nuclear Hormone Receptor NR4A1

W. Li, S. Hang, Y. Fang, S. Bae, Y. Zhang, G. Wang, M. D. McCurry, M. Bae, E. A. Franzosa, C. Huttenhower, L. Yao, A. S. Devlin, J. R. Huh

This study identifies a bacterial bile acid metabolite, isoalloLCA, that enhances Treg cell differentiation via NR4A1 and is reduced in inflammatory bowel disease patients.

bioRxiv · Jan 8, 2021Immunology

Bariatric surgery reveals a gut-restricted TGR5 agonist that exhibits anti-diabetic effects

S. N. Chaudhari, D. A. Harris, H. Aliakbarian, M. T. Henke, R. Subramaniam, A. H. Vernon, A. Tavakkoli, E. G. Sheu, A. S. Devlin

This study identifies CA7S, a gut-restricted TGR5 agonist that improves glucose tolerance in insulin-resistant mice by inducing GLP-1 secretion.

bioRxiv · Jan 10, 2020Biochemistry

Development of a Covalent Inhibitor of Gut Bacterial Bile Salt Hydrolases

A. A. Adhikari, T. C. Seegar, S. B. Ficarro, M. D. McCurry, D. Ramachandran, L. Yao, S. N. Chaudhari, S. Ndousse-Fetter, A. S. Banks, J. A. Marto, S. C. Blacklow, A. S. Devlin

This study develops a covalent inhibitor of gut bacterial bile salt hydrolases, showing it reduces BSH activity and deconjugated bile acids in mice.

bioRxiv · May 17, 2019Microbiology