Author

S. Ota

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Bioengineering· 2 Cancer Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Research Focus:differential expression· 4 Research Focus:cell-cell communication· 3 Approach:experimental assay· 3 Assay:flow cytometry· 3 Organism:human· 3 Approach:microscopy & imaging analysis· 2 Research Focus:batch correction / integration· 1

Frequent Co-Authors

K. Hattori· 3 shared K. Teranishi· 2 shared M. Yamashita· 2 shared R. Kojima· 2 shared Y. Goda· 2 shared Y. Kawamura· 2 shared Y. Yanagihashi· 2 shared A. Miura· 1 shared

Activity by Year

2021-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersBioengineering

K. Hattori

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Barcoding of small extracellular vesicles with CRISPR-gRNA enables comprehensive, subpopulation-specific analysis of their biogenesis/release regulators

K. Kunitake, T. Mizuno, K. Hattori, C. Oneyama, M. Kamiya, S. Ota, Y. Urano, R. Kojima

The paper introduces CIBER, a CRISPR-based method to barcode sEVs for subpopulation-specific analysis of their release regulators, identifying new regulators and characterizing sEV biogenesis.

bioRxiv · Sep 28, 2023Cell Biology

Artificial Intelligence Enables the Label-Free Identification of Chronic Myeloid Leukemia Cells with Mitochondrial Morphological Alterations

K. Suzuki, N. Watanabe, S. Torii, S. Arakawa, K. Ochi, S. Tsuchiya, K. Yamada, Y. Kawamura, S. Ota, N. Komatsu, S. Shimizu, M. Ando, T. Takaku

This study uses AI with flow cytometry to identify CML cells with mitochondrial morphological changes, enabling early diagnosis and monitoring of treatment response.

bioRxiv · Jul 26, 2023 · PreprintCancer Biology

High-throughput 3D imaging flow cytometry of adherent 3D cell cultures

M. Yamashita, M. Tamamitsu, H. Kirisako, Y. Goda, X. Chen, K. Hattori, S. Ota

This paper develops a high-throughput 3D imaging flow cytometry platform for analyzing spheroid models on hydrogel beads, revealing adhering cells have smaller nuclei with non-round surfaces.

bioRxiv · Jul 10, 2023 · PreprintBioengineering

Label-free ghost cytometry for manufacturing of cell therapy products

K. Teranishi, K. Wagatsuma, K. Toda, H. Nomaru, Y. Yanagihashi, H. Ochiai, S. Akai, E. Mochizuki, Y. Onda, K. Nakagawa, K. Sugimoto, S. Takahashi, H. Yamaguchi, S. Ota

This paper introduces label-free ghost cytometry (LF-GC) for cell therapy manufacturing, showing it can quantify cell count, viability, and identify cell subsets and impurities without staining.

bioRxiv · Jul 9, 2023Cell Biology

Pooled CRISPR screening of high-content cellular phenotypes by ghost cytometry

A. Tsubouchi, Y. An, Y. Kawamura, Y. Yanagihashi, Y. Murata, K. Teranishi, S. Ishiguro, H. Aburatani, N. Yachie, S. Ota

The paper introduces a ghost cytometry-based method for fast pooled CRISPR screening of high-content cellular phenotypes, including fluorescence and label-free modes, enabling genome-wide analysis of gene effects on cellular processes.

bioRxiv · Jan 26, 2023 · PreprintCell Biology

Droplet array-based platform for parallel optical analysis of dynamic extracellular vesicle secretion from single cells

K. Hattori, Y. Goda, M. Yamashita, Y. Yoshioka, R. Kojima, S. Ota

This study develops a droplet array platform to track single-cell extracellular vesicle secretion dynamics over time, revealing heterogeneity and the role of cell division in EV secretion.

bioRxiv · Apr 7, 2022Bioengineering

Two structurally different oomycete lipophilic MAMPs induce distinctive plant immune responses.

M. S. Monjil, H. Kato, S. Ota, K. Matsuda, N. Suzuki, S. Tenhiro, A. Tatsumi, S. Pring, A. Miura, M. Camagna, T. Suzuki, A. Tanaka, R. Terauchi, I. Sato, S. Chiba, , D. Takemoto

This study identifies two structurally distinct oomycete MAMPs, ceramides and diacylglycerols, that induce different plant immune responses through unique molecular patterns.

bioRxiv · Oct 22, 2021Plant Biology