H. Kato

Regulation of ROP GTPase cycling between active/inactive states is essential for vegetative organogenesis in Marchantia polymorpha

This study investigates the roles of ROP GTPase regulators in organogenesis of Marchantia polymorpha, showing that both GAPs and GEFs are essential for controlling the active/inactive cycle of MpROP.

Chemical inhibition of stomatal differentiation by perturbation of the master-regulatory bHLH heterodimer via an ACT-Like domain

This study identifies Stomidazolone as a chemical inhibitor of the bHLH heterodimer MUTE-SCREAM, disrupting stomatal differentiation in plants.

Control of cell fate specification and patterning by an ancestral microRNA

The paper shows that MpDCL1a is essential for miRNA biogenesis and regulates auxin synthesis, influencing cell identity and body development in the last common ancestor of land plants.

Characterization of an EG.5.1 clinical isolate in vitro and in vivo

This study characterizes the in vitro and in vivo properties of the EG.5.1 SARS-CoV-2 variant, showing increased transmissibility and altered antigenicity compared to XBB.1.5.

Induction of plant disease resistance by mixed oligosaccharide elicitors prepared from plant cell wall and crustacean shells

This study compares the elicitor activities of different oligosaccharides from plant cell walls and crustacean shells, showing that a mixture enhances disease resistance in tomato without inhibiting growth.

hnRNPM and ELAVL1 control type I interferon induction by promoting IRF3 phosphorylation downstream of both cGAS and RIG-I

Ketone-loading as A Novel Sports Nutrition Strategy: Chronic Ketone Supplementation Elicits Further Favorable Metabolic Changes in Keto-adapted Mice

This study shows that chronic exogenous ketone body administration in keto-adapted mice increases circulating ketone bodies and enhances gene expression related to fatty acid oxidation and energy homeostasis.

Inflammatory response induced in pulmonary embolic lung: Evaluation usinga reproducible murine pulmonary embolism model.

This paper establishes a reproducible murine pulmonary embolism model using small thrombi and evaluates the inflammatory response in the lung.

Nuclear auxin signaling is essential for organogenesis but not for cell survival in the liverwort Marchantia polymorpha

A very long chain fatty acid responsive transcription factor, MYB93, regulates lateral root development in Arabidopsis

The paper identifies MYB93 as a VLCFA-responsive transcription factor that regulates lateral root development in Arabidopsis by modulating cell wall organization gene expression.

TET1 attenuates human pluripotency-related heterogeneities and enhances differentiation capabilities

This study shows that adding TET1 to hiPSCs improves their differentiation capabilities and reduces heterogeneity by correcting DNA methylation and gene expression deviations.

The bHLH transcription factor MpHYPNOS regulates gemma dormancy in the liverwort Marchantia polymorpha

This study identifies MpHYPNOS as a key regulator of gemma dormancy in liverworts, showing it represses cell cycle genes and induces ABA biosynthesis through an ABA-independent pathway.

Engineering of an electrically charged hydrogel implanted into a traumatic brain injury model for stepwise neuronal tissue reconstruction

The paper describes a two-step method using charged hydrogels and neural stem cell injection to promote brain tissue reconstruction after traumatic injury.

Two structurally different oomycete lipophilic MAMPs induce distinctive plant immune responses.

This study identifies two structurally distinct oomycete MAMPs, ceramides and diacylglycerols, that induce different plant immune responses through unique molecular patterns.

Pathogen-derived 9-methyl sphingoid base is perceived by a lectin receptor kinase in Arabidopsis

The paper shows that oomycete-derived ceramide is cleaved into sphingoid base by ceramidase and recognized by an Arabidopsis receptor kinase, enhancing plant immunity.

RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infection

This study shows that activating the RIG-I receptor with synthetic RNA oligonucleotides before SARS-CoV-2 infection improves mouse survival and reduces viral load.

Stem cell therapy for skin regeneration using mesenchymal stem cells derived from the progeroid Werner syndrome-specific iPS cells

This study evaluates the efficacy of mesenchymal stem cells derived from Werner syndrome-induced pluripotent stem cells in treating skin ulcers, finding reduced angiogenic potential and improved healing with VEGF supplementation.

A highly attenuated vaccinia virus strain LC16m8-based vaccine for severe fever with thrombocytopenia syndrome

This paper develops and tests recombinant vaccinia virus vaccines against SFTS, showing they induce protective immunity and are safe in mice.

AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP-170

This study shows AMPK regulates cardiomyocyte shape by modulating microtubule turnover via CLIP-170 phosphorylation at intercalated discs.

Aberrant claudin-6-adhesion signal promotes endometrial cancer progression via estrogen receptor α

The paper shows that CLDN6 promotes endometrial cancer progression by activating estrogen receptor α through SFK/PI3K signaling, independent of ligand.

Lumi-Map, a real-time luciferase bioluminescence screen of mutants combined with MutMap, reveals Arabidopsis genes involved in PAMP-triggered immunity

Lumi-Map combines bioluminescence screening with MutMap to identify Arabidopsis genes involved in PAMP-triggered immunity, revealing three novel PTI-related genes.

Genome sequencing of ion-beam-induced mutants facilitates the detection of candidate genes responsible for phenotypes of mutants in rice

The paper uses whole-exome sequencing to identify mutations in ion-beam-induced rice mutants, finding high-impact mutations linked to mutant phenotypes.

Design principles of a minimal auxin response system

The paper identifies a minimal auxin response system in Marchantia polymorpha, showing that a single A-ARF activates gene expression while a B-ARF represses it, defining developmental zones of auxin response.

Epidemiological survey of serum titers from adults against various Gram-negative bacterial V-antigens

The paper measures serum titers against five Gram-negative bacterial V-antigens in adults and finds high cross-correlation between some antigens, suggesting potential for epidemiological studies.

Practical and safe method of cryopreservation for clinical application of human adipose-derived mesenchymal stem cells without a programmable freezer or serum

This study develops a practical cryopreservation method for human ADSCs without a programmable freezer or serum, showing viability over 18 months at -150°C with specific cryoprotectants.

Evolution of vascular plants through redeployment of ancient developmental regulators

This study traces the evolutionary origin and functional adaptation of the TMO5/LHW transcription factor complex in vascular plant development.

Ferroptosis is programmed by the coordinated regulation of glutathione and iron metabolism by BACH1

This study identifies BACH1 as a regulator of ferroptosis by modulating glutathione and iron metabolism, showing its role in myocardial infarction resistance.