Author

S. Pilon-Thomas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Physiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

K. A. Rejniak· 2 shared A. El-Kenawi· 1 shared A. Ibrahim-Hashim· 1 shared A. M. E. Ojwang'· 1 shared B. Evernden· 1 shared D. Abrahams· 1 shared D. Longo· 1 shared F. L. Locke· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersSystems Biology

K. A. Rejniak

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4 papers

Recent·Most cited

Histology-guided mathematical model of tumor oxygenation: sensitivity analysis of physical and computational parameters

A. M. E. Ojwang', S. Bazargan, J. O. Johnson, S. Pilon-Thomas, K. A. Rejniak

The paper develops a histology-guided tumor oxygenation model and finds it insensitive to most parameters but sensitive to large perturbations and boundary conditions.

bioRxiv · Mar 5, 2024 · PreprintSystems Biology

Branched-chain keto acids promote an immune-suppressive and neurodegenerative microenvironment in leptomeningeal disease

M. L. Khaled, Y. Ren, R. Kundalia, H. Alhaddad, Z. Chen, G. C. Wallace, B. Evernden, O. E. Ospina, M. Hall, M. Liu, L. N. F. Darville, V. Izumi, Y. A. Chen, S. Pilon-Thomas, P. A. Stewart, , I. Smalley

This study identifies branched-chain keto acid accumulation in leptomeningeal disease CSF, showing immune suppression and neurodegeneration, and shows that reducing BCKA improves outcomes in mouse models.

bioRxiv · Dec 18, 2023 · PreprintCancer Biology

Modeling vaccine-induced immunotherapy: treatment scheduling and robustness with virtual mice cohorts

P. Bhatt, M. Kambara, S. Pilon-Thomas, K. A. Rejniak, I. M. Chamseddine

The paper develops a mathematical model to test vaccine-induced immunotherapy protocols and identifies optimal treatment schedules that are robust across tumor heterogeneity using virtual mice cohorts.

bioRxiv · Aug 21, 2019 · PreprintCancer Biology

Lymph Nodes Inhibit T-cell Effector Functions Locally by Establishing Acidic Niches

H. Wu, V. Estrella, P. Enriquez-Navas, A. El-Kenawi, S. Russell, D. Abrahams, A. Ibrahim-Hashim, D. Longo, Y. Reshetnyak, K. Luddy, M. Damaghi, S. R. Pillai, M. Beatty, S. Pilon-Thomas, P. Swietach, r. gillies

The paper shows that acidic niches in lymph nodes inhibit T-cell effector functions by blocking lactic acid efflux and reducing glycolysis, keeping T-cells in a state of stasis.

bioRxiv · Jul 2, 2019 · PreprintPhysiology