Author

S. Seal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Biophysics· 1 Ecology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:imaging· 3 Research Focus:host-pathogen & immune response· 2 Approach:machine learning (classical)· 2 Research Focus:clustering· 1 Organism:Drosophila· 1 Organism:human· 1

Frequent Co-Authors

A. Bender· 2 shared A. E. Carpenter· 2 shared D. N. Basu· 2 shared I. Khan· 2 shared J. Carreras-Puigvert· 2 shared O. Spjuth· 2 shared A. Ramachandran· 1 shared A. T. Ly· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCell Biology

A. Bender

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A Decade in a Systematic Review: The Evolution and Impact of Cell Painting

S. Seal, M.-A. Trapotsi, O. Spjuth, S. Singh, J. Carreras-Puigvert, N. Greene, A. Bender, A. E. Carpenter

This paper reviews methodological advancements in Cell Painting over a decade, highlighting improvements in protocols, feature extraction, and machine learning applications for biological insights.

bioRxiv · May 4, 2024 · PreprintCell Biology

PATHOGEN GROWTH AND VIRULENCE DYNAMICS DRIVE THE HOST EVOLUTION AGAINST COINFECTIONS

S. Seal, D. N. Basu, K. Ghosh, A. Ramachandran, R. Kutum, T. N. Shelke, I. Gupta, I. Khan

This study shows that host evolution against coinfections is influenced by the growth and virulence dynamics of individual pathogens, with fast-acting pathogens hindering adaptive success.

bioRxiv · May 1, 2024Evolutionary Biology

Visualizing PIEZO1 Localization and Activity in hiPSC-Derived Single Cells and Organoids with HaloTag Technology

G. A. Bertaccini, I. Casanellas, E. L. Evans, J. L. Nourse, G. D. Dickinson, G. Liu, S. Seal, A. T. Ly, J. R. Holt, T. D. Wijerathne, S. Yan, E. E. Hui, J. J. Lacroix, M. M. Panicker, S. Upadhyayula, , M. M. Pathak

This study uses HaloTag technology to visualize PIEZO1 localization and activity in hiPSC-derived cells and organoids, enabling mechanotransduction studies with high temporal resolution.

bioRxiv · Dec 22, 2023Biophysics

From Pixels to Phenotypes: Integrating Image-Based Profiling with Cell Health Data Improves Interpretability

S. Seal, J. Carreras-Puigvert, A. E. Carpenter, O. Spjuth, A. Bender

This study introduces BioMorph space, which integrates Cell Painting and Cell Health data to improve the interpretability of morphological features and reveal compound mechanisms of action.

bioRxiv · Jul 14, 2023Cell Biology

CARCASS SCAVENGING RELAXES CHEMICAL-DRIVEN FEMALE INTERFERENCE COMPETITION

B. Bagchi, S. Seal, M. Raina, D. N. Basu, I. Khan

The paper shows that scavenging nutrient-rich carcasses reduces chemical-driven female interference competition in flour beetles by increasing fecundity and reducing quinone content.

bioRxiv · Jun 2, 2020Ecology

A staphylococcal cyclophilin carries a single domain and unfolds via the formation of an intermediate that preserves cyclosporin A binding activity

S. Seal, S. Polley, S. Sau

This study investigates the unfolding mechanism and domain structure of a staphylococcal cyclophilin, revealing a single domain with a flexible tail and reversible unfolding via an intermediate that retains cyclosporin A binding activity.

bioRxiv · Jan 3, 2019Biochemistry