Author

M. M. Pathak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Organism:human· 4 Assay:imaging· 4 Research Focus:cell type annotation· 2 Approach:microscopy & imaging analysis· 2 Research Focus:development & morphogenesis· 1 Assay:electrophysiology· 1

Frequent Co-Authors

E. L. Evans· 4 shared J. R. Holt· 4 shared A. T. Ly· 3 shared G. A. Bertaccini· 2 shared G. D. Dickinson· 2 shared H. Abuwarda· 2 shared I. Parker· 2 shared J. L. Nourse· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersBiophysics

E. L. Evans

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Visualizing PIEZO1 Localization and Activity in hiPSC-Derived Single Cells and Organoids with HaloTag Technology

G. A. Bertaccini, I. Casanellas, E. L. Evans, J. L. Nourse, G. D. Dickinson, G. Liu, S. Seal, A. T. Ly, J. R. Holt, T. D. Wijerathne, S. Yan, E. E. Hui, J. J. Lacroix, M. M. Panicker, S. Upadhyayula, , M. M. Pathak

This study uses HaloTag technology to visualize PIEZO1 localization and activity in hiPSC-derived cells and organoids, enabling mechanotransduction studies with high temporal resolution.

bioRxiv · Dec 22, 2023Biophysics

PIEZO1 regulates leader cell formation and cellular coordination during collective keratinocyte migration

J. Chen, J. R. Holt, E. L. Evans, J. S. Lowengrub, M. M. Pathak

This study investigates how PIEZO1 regulates leader cell formation and coordinated migration during keratinocyte wound healing, finding that PIEZO1 inhibits leader cell formation and disrupts coordinated directionality.

bioRxiv · Oct 13, 2022Biophysics

Single-particle tracking reveals heterogeneous PIEZO1 diffusion

A. T. Ly, J. A. Freites, G. A. Bertaccini, E. L. Evans, G. D. Dickinson, D. J. Tobias, M. M. Pathak

This study uses single-particle tracking to show PIEZO1 exhibits heterogeneous diffusion in the plasma membrane, with mobility influenced by membrane composition and activation state.

bioRxiv · Sep 30, 2022Biophysics

Membrane curvature governs the distribution of Piezo1 in live cells

S. Yang, X. Miao, S. Arnold, B. Li, A. T. Ly, H. Wang, M. Wang, X. Guo, M. M. Pathak, W. Zhao, C. D. Cox, Z. Shi

This study shows membrane curvature regulates Piezo1 distribution in live cells, with Piezo1 depletion from curved protrusions and enrichment in invaginations, and activation reduces filopodia formation.

bioRxiv · Jun 22, 2022Biophysics

Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing

J. R. Holt, W.-Z. Zeng, E. L. Evans, S.-H. Woo, S. Ma, H. Abuwarda, M. Loud, A. Patapoutian, M. M. Pathak

This study shows that PIEZO1 channel localization dynamics regulate keratinocyte migration and wound healing speed in mice.

bioRxiv · Oct 18, 2020Biophysics

Myosin-II mediated traction forces evoke localized Piezo1 Ca2+ flickers

K. Ellefsen, J. R. Holt, A. Chang, J. L. Nourse, J. Arulmoli, A. Mekhdjian, H. Abuwarda, F. Tombola, L. A. Flanagan, A. R. Dunn, I. Parker, M. M. Pathak

The paper shows that Myosin-II mediated traction forces cause localized Piezo1 Ca2+ flickers in cells without external forces.

bioRxiv · May 13, 2019Biophysics