Author

S. Sivasankar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 6 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 4 Assay:fluorescence / live-cell microscopy· 3 Approach:mechanistic / dynamical model· 2 Research Focus:protein folding & dynamics· 2 Approach:Bayesian inference· 1 Research Focus:cell-cell communication· 1 Organism:human· 1

Frequent Co-Authors

B. Xie· 3 shared A. V. Priest· 2 shared B. M. Gumbiner· 2 shared I. Sgouralis· 2 shared M. Levitus· 2 shared O. M. Shafraz· 2 shared O. Shafraz· 2 shared S. Jazani· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

B. Xie

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Strengthening E-cadherin adhesion via antibody mediated binding stabilization.

B. Xie, S. Xu, L. Schecterson, B. M. Gumbiner, S. Sivasankar

This study identifies how the monoclonal antibody 66E8 stabilizes E-cadherin adhesion by stabilizing the strand-swap dimer conformation through electrostatic interactions.

bioRxiv · Jul 4, 2023Biophysics

Light Activated BioID (LAB): an optically activated proximity labeling system to study protein-protein interactions.

O. Shafraz, C. M. O. Davis, S. Sivasankar

The paper introduces LAB, a light-activated proximity labeling system that improves spatial and temporal control over protein-protein interaction studies by using split-TurboID and photodimeric proteins.

bioRxiv · Oct 22, 2022Biochemistry

Molecular mechanism for strengthening E-cadherin adhesion using a monoclonal antibody

B. Xie, A. Maker, A. V. Priest, D. M. Dranow, J. N. Phan, T. E. Edwards, B. Staker, P. J. Myler, B. M. Gumbiner, S. Sivasankar

This study identifies how the monoclonal antibody 19A11 strengthens E-cadherin adhesion through a salt bridge that stabilizes the strand-swap dimer interface.

bioRxiv · Mar 6, 2022Biophysics

Mapping transmembrane binding partners for E-cadherin ectodomains.

O. Shafraz, B. Xie, S. Yamada, S. Sivasankar

The paper identifies novel transmembrane protein interactions of E-cadherin ectodomains using proximity labeling and single molecule binding assays.

Proceedings of the National Academy of Sciences · Nov 23, 2020Peer-reviewedCell Biology

Robust scan synchronized force-fluorescence imaging.

P. Schmidt, J. Lajoie, S. Sivasankar

The paper introduces a synchronized AFM-confocal fluorescence microscope platform to visualize force-induced changes in fluorescent protein distribution in live cells.

bioRxiv · May 15, 2020Biophysics

Inside-out regulation of E-cadherin conformation and adhesion

R. Koirala, A. V. Priest, C.-F. Yen, J. S. Cheah, W.-J. Pannekoek, M. Gloerich, S. Yamada, S. Sivasankar

This study shows vinculin regulates cadherin conformation and adhesion by converting weak X-dimers to strong strand-swap dimers through myosin II-dependent cytoskeletal tension changes.

bioRxiv · May 2, 2020Biophysics

Pitching single focus confocal data analysis one photon at a time with Bayesian nonparametrics

M. Tavakoli, S. Jazani, I. Sgouralis, O. M. Shafraz, B. Donaphon, S. Sivasankar, M. Levitus, S. Presse

This paper introduces a Bayesian nonparametric method to analyze single-focus confocal data by directly processing photon arrival times, enabling faster and more efficient molecular dynamics analysis than traditional methods.

bioRxiv · Apr 16, 2020Biophysics

An Alternative Framework for Fluorescence Correlation Spectroscopy

S. Jazani, I. Sgouralis, O. M. Shafraz, M. Levitus, S. Sivasankar, S. Presse

This paper introduces a new analysis method for fluorescence correlation spectroscopy that enables faster and less phototoxic analysis of single molecule fluorescence confocal microscopy data.

bioRxiv · Apr 16, 2019Biophysics