Author

S. Speaks

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Organism:human· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. C. Eddy· 2 shared A. D. Kenney· 2 shared A. Forero· 2 shared A. Zani· 2 shared C. Cai· 2 shared J. Ma· 2 shared J. S. Yount· 2 shared L. Zhang· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersMicrobiology

A. C. Eddy

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Innate immune control of influenza virus interspecies adaptation

P. J. Denz, S. Speaks, A. D. Kenney, A. C. Eddy, J. L. Papa, J. Roettger, S. C. Scace, E. A. Hemann, A. Forero, R. J. Webby, A. S. Bowman, J. S. Yount

This study shows that IFITM3 deficiency in mice allows avian influenza viruses to infect and adapt more effectively, suggesting a role for IFITM3 in preventing zoonotic virus emergence.

bioRxiv · Aug 23, 2023 · PreprintMicrobiology

Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation

S. Speaks, A. Zani, A. Solstad, A. Kenney, M. McFadden, L. Zhang, A. C. Eddy, A. O. Amer, R. Robinson, C. Cai, J. Ma, E. Hemann, A. Forero, J. Yount

This study shows that gasdermin D promotes influenza virus-induced mortality by amplifying neutrophil-driven inflammation.

bioRxiv · Mar 8, 2023Immunology

Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosis

A. D. Kenney, S. L. Aron, C. Gilbert, N. Kumar, P. Chen, A. Eddy, L. Zhang, A. Zani, N. Vargas-Maldonado, S. Speaks, J. Kawahara, P. J. Denz, L. Dorn, F. Accornero, J. Ma, , J. S. Yount

This study shows that influenza virus directly infects cardiomyocytes, causing heart dysfunction and fibrosis, challenging the prevailing model of indirect cardiotoxicity.

bioRxiv · Oct 27, 2021Immunology