C. Cai

Suppression of T cell function by phosphoethanolamine, a metabolite enriched in tumor interstitial fluid

This study identifies phosphoethanolamine as a key metabolite in tumor interstitial fluid that suppresses T cell function by inhibiting TCR signaling.

Non-physiologic interaction of MG53 with insulin receptor and lack of evidence for MG53's role in controlling insulin-stimulated Akt phosphorylation in muscle, heart and liver tissues.

This study investigates whether MG53 interacts with the insulin receptor and affects Akt phosphorylation in muscle, heart, and liver tissues, finding low binding affinity and no effect on insulin signaling.

A new story of four Hexapoda classes: Protura as the sister to all other hexapods

This study resolves the phylogenetic relationships of early hexapods, finding Protura as the earliest-diverging lineage and supporting a new classification of hexapod evolution.

Novel psilocin prodrugs with altered pharmacological properties as candidate therapies for treatment-resistant anxiety disorders

This paper identifies novel psilocin prodrugs with altered pharmacokinetics and reduced psychedelic effects, maintaining therapeutic benefits for anxiety disorders.

Consolidated Bioprocessing of Lignocellulosic Biomass Poplar to Produce Short-Chain Esters by Clostridium thermocellum

Bayesian Inference for Brain Source Imaging with Joint Estimation of Structured Low-rank Noise

This paper introduces a Bayesian framework for brain source imaging that jointly estimates low-rank noise and sparse brain activity, outperforming existing methods on simulated and real data.

Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation

This study shows that gasdermin D promotes influenza virus-induced mortality by amplifying neutrophil-driven inflammation.

A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression

This study identifies a cleaved form of METTL3, METTL3a, which enhances METTL3-WTAP interaction and promotes breast cancer progression through m6A methylation and mTOR activation.

Angiopoietin-like 4 shapes the intrahepatic T-cell landscape via eIF2α signalingduring steatohepatitis in diet-induced NAFLD.

The paper identifies Angptl4's role in shaping intrahepatic T-cell activation via eIF2α signaling during fibrosis in diet-induced NAFLD.

CXCL12 in late-stage osteoblasts and osteocytes is required for load induced bone formation in mice

This paper shows that CXCL12 in late-stage osteoblasts and osteocytes is essential for load-induced bone formation in mice, as its absence reduces bone formation and recombinant CXCL12 rescues this phenotype.

Subcellular Redox Responses Reveal Different Cu-dependent Antioxidant Defenses between Mitochondria and Cytosol

This study investigates Cu-dependent antioxidant defenses in mitochondria and cytosol using redox sensors and proteomics, revealing distinct redox responses and protein changes in each compartment.

Longitudinal white matter alterations in SIVmac239 infected rhesus monkeys with and without regular cART treatment

This study tracks white matter changes in SIV-infected rhesus monkeys with and without cART, finding early alterations at 4 weeks and varying cART effects over time.

Three amphioxus reference genomes reveal gene and chromosome evolution of chordates

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

Interferon-induced transmembrane protein 3 (IFITM3) limits lethality of SARS-CoV-2 in mice

This study shows that IFITM3 protects mice from severe SARS-CoV-2 infection by limiting viral spread and inflammation, as demonstrated through knockout mouse models.

Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosis

This study shows that influenza virus directly infects cardiomyocytes, causing heart dysfunction and fibrosis, challenging the prevailing model of indirect cardiotoxicity.

Compositional phylogenomic modelling resolves the 'Zoraptera problem': Zoraptera are sister to all other polyneopteran insects

This study resolves the Zoraptera placement in insect phylogeny, finding Zoraptera as the earliest-diverging polyneopteran order and providing a Devonian origin for winged insects.

Integrated phylogenomics and fossil data illuminate the evolution of beetles

This paper integrates phylogenomic data and fossil records to refine the evolutionary timescale and classification of beetles, revealing a late Carboniferous origin and Cretaceous diversification.

Single cell multi-omics reveals early elevated function and multiple fates within human progenitor exhausted CD8+ T cells

The paper identifies progenitor cells of T-cell exhaustion in acute HCV infection and shows their functional and phenotypic characteristics.

Broad neutralizing nanobody against SARS-CoV-2 engineered from pre-designed synthetic library

The paper reports the discovery of a neutralizing nanobody, VHH60, effective against SARS-CoV-2 and its variants, with high potency and protective efficacy in mice.

A Pan-Cancer Census of Dominant Tumor Immune Archetypes

The paper identifies dominant immune system archetypes across 364 tumors from 12 cancer types using flow cytometry and transcriptomic data, linking them to tumor biology classifications.

Liver X Receptor; Controls Hepatic Stellate Cell Activation via Hedgehog Signaling

This study shows that LXRβ suppresses hepatic stellate cell activation via inhibition of Hedgehog signaling, offering a potential therapeutic target for liver fibrosis without causing liver steatosis.

A non-canonical EZH2 function sensitizes solid tumors to genotoxic stress

This study shows EZH2 inhibitors inhibit CRPC growth by downregulating DNA repair genes, making cancer cells more sensitive to genotoxic stress.

Robust Estimation of Noise for Electromagnetic Brain Imaging with the Champagne Algorithm

This paper introduces a noise estimation method for electromagnetic brain imaging that improves source reconstruction without baseline data.

Small molecule FGF23 inhibitors increase serum phosphate and improve skeletal abnormalities in Hyp mice

Species packing and the latitudinal gradient in beta-diversity

The paper tests whether beta-diversity contributes to the latitudinal gradient in species richness by analyzing tree species data across East Asia.

Mitotic spindle disassembly in human cells relies on CRIPT-bearing hierarchical redox signals

The paper shows CRIPT enables mitotic spindle disassembly via redox-dependent interactions with tubulin, and mutations disrupt this process.

Arabidopsis Myosins XI Are Involved in Exocytosis of Cellulose Synthase Complexes

This study shows that myosin XI and the actin cytoskeleton are essential for delivering cellulose synthase complexes to the plasma membrane in Arabidopsis, affecting cellulose biosynthesis.

TCR-pMHC bond length controls TCR ligand discrimination

This study shows that TCR-pMHC bond length controls TCR ligand discrimination by affecting CD3ζ ITAM phosphorylation and downstream signaling.

An assessment of the interactions between climatic conditions and genetic characteristic on the agricultural performance of soybeans grown in Northeast Asia

This study assesses how climatic conditions and genetic traits influence soybean agricultural performance in Northeast Asia, finding that day length significantly affects flowering time and stem length, while yield varies by cultivar.

Systematic Discovery of the Functional Impact of Somatic Genome Alterations in Individual Tumors through Tumor-specific Causal Inference

This paper introduces a tumor-specific causal inference framework to identify causative somatic genome alterations and their impact on molecular phenotypes in individual tumors.