L. Rigouts

Phylogenomic and genomic analysis reveals unique and shared genetic signatures of Mycobacterium kansasii complex species

This study analyzes 665 Mycobacterium kansasii complex strains to identify unique and shared genomic signatures, revealing lineage splits, virulence factors, and drug resistance mechanisms.

Reconstituting the genus Mycobacterium

This study evaluates the proposed split of the genus Mycobacterium into five new genera and concludes that the original genus label is better supported.

Characterization of genomic variants associated with resistance to bedaquiline and delamanid in naïve Mycobacterium tuberculosis clinical strains

This study identifies genetic mutations associated with resistance to bedaquiline and delamanid in Mycobacterium tuberculosis strains using whole genome sequencing and in silico analysis.

An African origin for Mycobacterium bovis

The paper traces the origin of Mycobacterium bovis to East Africa and identifies its global dispersal patterns through phylogenetic and phylogeographic analysis.

A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region

The paper identifies a new lineage of Mycobacterium tuberculosis complex, Lineage 8, found in the African Great Lakes region, and shows its evolutionary relationship to known lineages.

Comparative Genomics Shows Differences in the Electron Transport and Carbon Metabolic Pathways of Mycobacterium africanum relative to Mycobacterium tuberculosis and suggests an adaptation to low oxygen tension

The paper compares the genomes of Mycobacterium africanum and Mycobacterium tuberculosis to identify mutations in electron transport and carbon metabolic pathways, suggesting adaptations to low oxygen environments.

How well do routine molecular diagnostics detect rifampicin heteroresistance in Mycobacterium tuberculosis?

This study evaluates the detection limits of rifampicin heteroresistance in four RDTs using mixed strains and Deeplex-MycTB, finding significant variation in sensitivity across tests.

Genome wide association with quantitative resistance phenotypes in Mycobacterium tuberculosis reveals novel resistance genes and regulatory regions

This study identifies novel resistance genes and regulatory regions in Mycobacterium tuberculosis using genome-wide association analysis of drug resistance phenotypes.

Reference Set of Mycobacterium tuberculosis Clinical Strains: A tool for research and product development

The paper introduces a reference set of 20 genetically characterized Mycobacterium tuberculosis clinical strains to enhance TB research by incorporating phylogenetic diversity beyond the commonly used lab strains.

Xpert Ultra can unambiguously identify specific rifampicin resistance-conferring mutations

The paper evaluates Xpert Ultra's ability to identify rifampicin resistance mutations by analyzing the relationship between rpoB mutations, Ultra probes, and melting temperature shifts.