Cell BiologybioRxivPreprint
PFKFB3 DEPLETION ACTIVATES β-CELL REPLICATION BY CELL COMPETITIVE CULLING OF COMPROMISED β-CELLS UNDER STRESS
J. Min, F. Ma, M. Pellegrini…·S. Tudzarova
This study shows that PFKFB3 depletion in β-cells under diabetogenic stress increases β-cell replication by removing damaged cells, improving β-cell function and mass.
DOI 10.1101/2021.04.07.438857