S.-J. Chen

Machine learning-inferred and energy landscape-guided analyses reveal kinetic determinants of CRISPR/Cas9 gene editing

This study combines machine learning and energy landscape analysis to identify kinetic determinants of CRISPR/Cas9 gene editing, revealing a three-state mechanism and critical nucleotides for cleavage efficiency.

Propagation of a rapid cell-to-cell H2O2 signal over long distances in a monolayer of cardiomyocyte cells

The paper identifies a rapid long-distance H2O2 signaling pathway in cardiomyocyte monolayers that involves superoxide production, gap junctions, and protein abundance changes.

Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice

This study shows that lactational exposure to Triclosan in mice causes fatty liver disease by disrupting metabolic pathways involving PERK-eIF2-ATF4-PPAR.