Sagar

Tissue imprinting defines functional mosaic of dermal macrophages

This study shows that dermal macrophages can maintain functional diversity without monocyte replenishment, but require monocytes during bacterial infections.

Streptococcal meningoencephalitis dynamically shapes developmental monocyte and macrophage trajectories in the CNS

This study shows that streptococcal meningoencephalitis alters monocyte and macrophage dynamics in the dura by shifting their origin from skull bone marrow to peripheral sources and increasing MDP-Mo-derived cells.

Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment

This study identifies a PGE2-autophagy-glutathione axis that enables CD8+ T cells to adapt metabolically to the intestinal microenvironment.

Ex vivo detection of SARS-CoV-2-specific CD8+ T cells: rapid induction, prolonged contraction, and formation of functional memory

This study identifies SARS-CoV-2-specific CD8+ T-cell responses, showing their rapid induction, prolonged contraction, and functional memory formation compared to antibody responses.

Deciphering the Regulatory Landscape of γδ T Cell Development by Single-Cell RNA-Sequencing

This study uses single-cell RNA-sequencing to uncover the developmental trajectory of γδ T cells, identifying c-MAF as a key regulator of IL-17-producing γδ T cell differentiation.