D. R. Littman

Niche-specific macrophage loss promotes skin capillary aging

This study shows that loss of capillary-associated macrophages with age impairs vascular repair and perfusion, revealing limitations in macrophage homeostatic renewal in skin capillaries.

Microbiota-instructed regulatory T cell differentiation is mediated by a distinct RORγt+ antigen presenting cell subset

This study identifies a distinct RORγt+ antigen presenting cell subset that mediates microbiota-driven regulatory T cell differentiation, revealing a mechanism for maintaining immune tolerance.

Gut microbiome dysbiosis during COVID-19 is associated with increased risk for bacteremia and microbial translocation.

The paper shows that gut microbiome dysbiosis in COVID-19 patients is linked to increased risk of bacteremia and microbial translocation.

Epigenetic Programming during thymic development sets the stage for optimal function in effector T cells via DNA demethylation

The paper shows DNA demethylation during thymic development is essential for proper function of stimulus-responsive elements in effector T cells, impacting gene expression and immune response.

Arkadia-SKI/SnoN signaling cascade differentially regulates TGF-β-induced iTreg and Th17 cell differentiation

This study identifies Arkadia-SKI/SnoN signaling as a regulator of TGF-β-induced iTreg differentiation, distinct from Th17 cell differentiation.

RORα enforces stability of the T-helper-17 cell effector program

This study shows ROR is essential for maintaining Th17 cell effector function through cooperative binding with ROR{gamma}t to an enhancer element.

Niche-selective inhibition of pathogenic Th17 cells by targeting metabolic redundancy

This study shows that targeting Gpi1 selectively inhibits pathogenic Th17 cells in autoimmune diseases while sparing homeostatic Th17 cells.

Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes

This study identifies redundant cytokine signals, particularly IL-6, IL-21, and IL-23, that drive Th17 cell differentiation in mesenteric lymph nodes induced by segmented filamentous bacteria.

VIP-producing enteric neurons interact with innate lymphoid cells to regulate feeding-dependent intestinal epithelial barrier functions

This study shows that VIP-producing enteric neurons interact with ILC3 to regulate intestinal barrier functions and nutrient absorption during feeding.

Distinct polysaccharide growth profiles of human intestinal Prevotella copri isolates

This study examines polysaccharide growth profiles of 83 P. copri isolates from 11 donors, revealing genomic and functional differences in polysaccharide utilization.

Specific targeting of intestinal Prevotella copri by a Listeria monocytogenes bacteriocin

This study identifies a Listeria bacteriocin that specifically targets Prevotella copri, showing microbiota-dependent effects on Listeria infection in mice.

Serum Amyloid A Proteins Induce Pathogenic TH17 Cells and Promote Inflammatory Disease

This study shows serum amyloid A proteins drive pathogenic TH17 cell differentiation and promote inflammatory disease through STAT3-activating cytokines.

The Prevotella copri complex comprises four distinct clades that are underrepresented in Westernised populations

The study identifies four distinct clades within the Prevotella copri complex, showing reduced prevalence in Westernised populations compared to non-Westernised ones.

A comprehensive map of the dendritic cell transcriptional network engaged upon innate sensing of HIV

This study maps the transcriptional network in HIV-1 infected dendritic cells, identifying key regulators of interferon response and maturation.

Deciphering the Regulatory Landscape of γδ T Cell Development by Single-Cell RNA-Sequencing

This study uses single-cell RNA-sequencing to uncover the developmental trajectory of γδ T cells, identifying c-MAF as a key regulator of IL-17-producing γδ T cell differentiation.

Transcriptional regulatory networks that promote and restrict identities and functions of intestinal innate lymphoid cells

This study identifies transcriptional regulatory networks in intestinal ILC subsets, revealing key transcription factors and their roles in lineage identity and plasticity.

c-Maf-dependent regulatory T cells mediate immunological tolerance to intestinal microbiota

This study identifies c-Maf-dependent regulatory T cells that suppress inflammation caused by the pathobiont Helicobacter hepaticus, preventing colitis in mice.