Author

S. Scheres

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 9

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 8 Research Focus:protein structure prediction· 8 Research Focus:benchmarking· 4 Approach:deep learning· 4 Approach:experimental assay· 3 Organism:human· 3 Approach:Bayesian inference· 2 Research Focus:software / tool· 2

Frequent Co-Authors

J. Zivanov· 4 shared T. Nakane· 3 shared A. Burt· 2 shared D. Kimanius· 2 shared E. Pyle· 2 shared G. Murshudov· 2 shared A. G. Murzin· 1 shared A. Kotecha· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersBiophysics

J. Zivanov

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9 papers

Recent·Most cited

An image processing pipeline for electron cryo-tomography in RELION-5

A. Burt, B. Toader, R. Warshamanage, A. von Kugelgen, E. Pyle, J. Zivanov, D. Kimanius, T. A. M. Bharat, S. Scheres

The paper introduces an image processing pipeline for electron cryo-tomography in RELION-5, enabling automated atomic model building from tomographic data.

bioRxiv · Apr 26, 2024Biophysics

DynaMight: estimating molecular motions with improved reconstruction from cryo-EM images

J. Schwab, D. Kimanius, A. Burt, T. Dendooven, S. Scheres

DynaMight improves cryo-EM reconstruction by estimating molecular motions through 3D deformation learning and error estimation using VAEs.

bioRxiv · Oct 18, 2023Biophysics

A Bayesian approach to single-particle electron cryo-tomography in RELION-4.0

J. Zivanov, J. Oton, Z. Ke, A. von Kügelgen, E. Pyle, K. Qu, D. Morado, D. Castano-Diez, G. Zanetti, T. Bharat, J. Briggs, S. Scheres

The paper introduces a Bayesian method for improving cryo-ET data analysis in RELION-4.0, enabling higher-resolution structure determination from multiple particles.

bioRxiv · Feb 28, 2022Biophysics

High-throughput cryo-EM structure determination of amyloids

S. Lövestam, S. Scheres

This paper describes a high-throughput cryo-EM approach for determining amyloid structures, including a new filament picking algorithm and image processing strategies in Relion.

Faraday Discussions · Jan 1, 2022Peer-reviewedBiophysics

Single-particle cryo-EM at atomic resolution

T. Nakane, A. Kotecha, A. Sente, G. McMullan, S. Masiulis, P. M. G. E. Brown, I. T. Grigoras, L. Malinauskaite, T. Malinauskas, J. Miehling, L. Yu, D. Karia, E. V. Pechnikova, E. de Jong, J. Keizer, , S. Scheres

This paper demonstrates achieving atomic resolution cryo-EM structures for membrane proteins and apo-ferritin using advanced hardware, enabling detailed structural analysis and hydrogen bonding visualization.

Nature · Oct 21, 2020Peer-reviewedBiophysics

Estimation of high-order aberrations and anisotropic magnification from cryo-EM datasets in RELION-3.1

J. Zivanov, T. Nakane, S. Scheres

The paper introduces methods to estimate high-order aberrations and anisotropic magnification in cryo-EM data, improving 3D reconstruction resolution when applicable, and implements them in RELION-3.1.

IUCrJ · Feb 11, 2020Peer-reviewedBiophysics

Amyloid structure determination in RELION-3.1

S. Scheres

This paper introduces a new method in RELION-3.1 to improve amyloid structure determination by reducing local optima issues in helical reconstruction.

Acta Crystallographica Section D Structural Biology · Jan 30, 2020Peer-reviewedBiophysics

A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis

J. Zivanov, T. Nakane, S. Scheres

The paper introduces a Bayesian method for correcting beam-induced motion in cryo-EM single-particle analysis, showing improved performance over existing methods in RELION-3.

bioRxiv · Aug 3, 2018Biophysics

Structures of filaments from Pick’s disease reveal a novel tau protein fold

B. Falcon, W. Zhang, A. G. Murzin, G. Murshudov, H. J. Garringer, R. Vidal, R. A. Crowther, B. Ghetti, S. Scheres, M. Goedert

This paper determines the structure of tau filaments from Pick’s disease using cryo-EM, revealing a novel tau protein fold distinct from Alzheimer's disease filaments.

bioRxiv · Apr 16, 2018Biophysics