P. Hoffmann

Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR-/- mice.

This study shows that fenretinide reduces obesity and fatty liver but increases ceramides via Smpd3, worsening atherosclerosis in LDLR-/- mice.

The guanine nucleotide exchange factor Rin-like acts as a gatekeeper for T follicular helper cell differentiation via regulating CD28 signaling

This study identifies Rin-like as a negative regulator of Tfh differentiation in mice and humans, showing its role in CD28 signaling and endocytosis.

Magnetic Enrichment of Immuno-Specific Extracellular Vesicles for Mass Spectrometry Using Biofilm-Derived Iron Oxide Nanowires

This paper develops a method to enrich immuno-specific extracellular vesicles using magnetic iron oxide nanowires for mass spectrometry, showing comparable performance to commercial beads.

JAMMIT Analysis Defines 2 Semi-Independent Immune Processes Common to 29 Solid Tumors

The paper introduces JAMMIT, an algorithm that identifies three immune-related immunophenotypes common to 29 solid tumors using TCGA data.

The Unconventional Self-Cleavage of Selenoprotein K

This paper identifies selenok's self-cleavage activity and its specific interaction sites, suggesting a regulatory role in its protein interactions and cellular functions.

Architecture of cell-cell junctions in situ reveals a mechanism for bacterial biofilm inhibition

The paper reveals the structure and function of CdrA in Pseudomonas aeruginosa biofilms, showing how it mediates cell-cell interactions and how targeting it can inhibit biofilm formation.

Genetic manipulation of the Brassicaceae smut fungus Thecaphora thlaspeos

The paper presents a transformation protocol for Thecaphora thlaspeos, enabling genetic manipulation and generating reporter strains to study mating and virulence mechanisms.

Degradation of mixed-linkage (1,3;1,4)-β-D-glucan in maize is mediated by the CAL1 licheninase

The paper identifies CAL1 as a licheninase responsible for degrading mixed-linkage (1,3;1,4)-β-D-glucan in maize, showing its role in regulating MLG content and saccharification efficiency.