Autophagy mediates cancer cell resistance to doxorubicin induced by the Programmed Death 1/Programmed Death Ligand 1 immune checkpoint axis
L. Minassian, D. Sanwalka, J.-F. Pare, S. Macdonald-Goodfellow, R. L. Sutherland, A. Ghaffari, C. L. Margerum, M. Koti, A. W. B. Craig, T. Cotechini, D. R. Siemens, E. Chan, C. H. Graham
This study shows that PD-1/PD-L1 signaling induces autophagy in cancer cells, contributing to drug resistance, and suggests combining PD-1/PD-L1 blockers with autophagy inhibitors could improve chemotherapy effectiveness.
bioRxiv · Jan 17, 2023 · PreprintCancer Biology