The paper uses scRNA-seq to analyze signaling between hematopoietic stem/progenitor cells and their niches in AML, identifying inflammatory niche remodeling as a factor affecting tissue failure and patient outcome.

bioRxiv · May 5, 2023 · PreprintCancer Biology

An IL-1β driven neutrophil-stromal cell axis fosters a BAFF-rich microenvironment in multiple myeloma

M. M. de Jong, C. Fokkema, N. Papazian, T. van Heusden, M. Vermeulen, R. Hoogenboezem, G. van Beek, S. Tahri, M. A. Sanders, P. van de Woestijne, F. Gay, P. Moreau, M. Büttner-Herold, H. Bruns, M. van Duin, , T. Cupedo

The paper identifies a neutrophil-stromal cell feedback loop in multiple myeloma that promotes BAFF-rich inflammation, persisting after treatment and suggesting dual targeting strategies.

bioRxiv · Mar 3, 2023 · PreprintImmunology

Immune-mediated tumor control in the 5TGM1 transfer model of multiple myeloma

Z. Kellermayer, S. Tahri, M. M. E. De Jong, N. Papazian, C. Fokkema, R. Hoogenboezem, M. A. Sanders, L. Boon, C. Den Hollander, A. Broijl, P. Sonneveld, T. Cupedo

This study uses a murine model to show that C57Bl/6 mice can control multiple myeloma through IFN-gamma-dependent immune responses, highlighting the model's utility for studying anti-myeloma immunity.

bioRxiv · Jan 18, 2023 · PreprintImmunology

Yap1-driven intestinal repair is controlled by group 3 innate lymphoid cells

M. Romera-Hernandez, P. Aparicio-Domingo, N. Papazian, J. J. Karrich, F. Cornelissen, R. M. Hoogenboezem, J. N. Samsom, T. Cupedo

This study identifies that ILC3-driven intestinal repair relies on Hippo-Yap1 signaling and Src family kinases, independent of IL-22 and Stat3.

bioRxiv · Sep 16, 2019Immunology