MicrobiologybioRxiv
CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy
C. Sharp, B. H. Thompson, T. J. Nash…·E. R. Gaunt
This paper engineers an influenza A virus with increased CpG content, showing it is attenuated in mice but replication competent in vaccine propagation systems, suggesting a new strategy for live attenuated vaccines.