Author

F. Grey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 8 Approach:experimental assay· 6 Organism:human· 4 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:variant calling· 2

Frequent Co-Authors

P. Digard· 4 shared Y.-T. Lin· 3 shared A. Wickenhagen· 2 shared C. Sharp· 2 shared E. R. Gaunt· 2 shared P. Simmonds· 2 shared R. M. Pinto· 2 shared S. J. Wilson· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

P. Digard

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Zoonotic avian influenza viruses evade human BTN3A3 restriction

R. M. Pinto, S. Bakshi, S. Lytras, M. K. Zakaria, S. Swingler, J. C. Worrell, V. Herder, M. Varjak, N. Cameron-Ruiz, M. Collados-Rodriguez, M. Varela, A. Wickenhagen, C. Loney, Y. Pei, J. Hughes, , M. Palmarini

This study identifies BTN3A3 as a human restriction factor that inhibits avian influenza viruses but not human IAVs, with resistance linked to specific NP mutations.

bioRxiv · Jun 14, 2022 · PreprintMicrobiology

CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy

C. Sharp, B. H. Thompson, T. J. Nash, O. Lee, R. M. Pinto, L. Thorley, Y.-T. Lin, S. Sives, H. Wise, S. M. R. Clohisey, F. Grey, L. Vervelde, P. Simmonds, P. Digard, E. R. Gaunt

This paper engineers an influenza A virus with increased CpG content, showing it is attenuated in mice but replication competent in vaccine propagation systems, suggesting a new strategy for live attenuated vaccines.

bioRxiv · Apr 29, 2022Microbiology

Jaagsiekte sheep retrovirus infection induces changes in microRNA expression in the ovine lung

M. Contreras Garcia, A. E. Karagianni, D. Vasoya, S. Jayaraman, Y.-T. Lin, A. R. Wood, M. Dagleish, C. Cousens, M. Watson, F. Grey, D. J. Griffiths

This study identifies differentially expressed microRNAs in JSRV-infected ovine lung, showing upregulation of miR-182, miR-183, miR-96, and miR-135b, which are associated with oncogenic pathways in human lung cancer.

bioRxiv · Oct 27, 2021 · PreprintMicrobiology

Stem cell-derived macrophages as a new platform for studying host-pathogen interactions in livestock

S. Meek, T. Watson, L. Eory, G. McFarlane, F. J. Wynne, S. McCleary, L. E. M. Dunn, E. M. Charlton, C. Craig, B. Shih, T. Regan, R. M. Taylor, L. Sutherland, A. Gossner, C. Chintoan-Uta, , T. Burdon

The paper uses stem cell-derived macrophages from livestock to study host-pathogen interactions, showing they can be infected by important viruses and genetically modified.

bioRxiv · Sep 10, 2021Immunology

Cytomegaloviral determinants of CD8+ T cell programming and RhCMV/SIV vaccine efficacy

D. Malouli, S. G. Hansen, M. H. Hancock, C. M. Hughes, J. C. Ford, R. M. Gilbride, A. B. Ventura, D. Morrow, H. Taher, L. S. Uebelhoer, M. R. McArdle, C. R. Papen, R. Espinosa Trethewy, K. Oswald, R. Shoemaker, , L. J. Picker

This study identifies eight genes in two RhCMV regions that control unconventional CD8+ T cell responses and vaccine efficacy against SIV challenge.

bioRxiv · Sep 30, 2020Immunology

Intra-genome variability in the dinucleotide composition of SARS-CoV-2

P. Digard, H.-M. Lee, C. Sharp, F. Grey, E. R. Gaunt

The paper analyzes CpG dinucleotide composition in SARS-CoV-2 and other coronaviruses to understand its role in replication and cross-species transmission.

bioRxiv · May 8, 2020Evolutionary Biology

Human cytomegalovirus evades ZAP detection by suppressing CpG dinucleotides in the major immediate early genes.

Y.-T. Lin, S. Chiweshe, D. McCormick, A. Raper, A. Wickenhagen, V. R. DeFilippis, E. Gaunt, P. Simmonds, S. J. Wilson, F. Grey

This study shows HCMV evades ZAP detection by suppressing CpG dinucleotides in its IE1 gene, and TRIM25 regulates ZAP isoform expression.

bioRxiv · Jan 7, 2020Microbiology

Asparagine deprivation causes a reversible inhibition of Human Cytomegalovirus acute virus replication

C.-H. Lee, S. Griffiths, P. Digard, N. T. Pham, M. Auer, J. Haas, F. Grey

This study identifies asparagine as a critical factor for HCMV replication through a large-scale siRNA screen, showing that its depletion inhibits virus replication but allows recovery with exogenous asparagine.

mBio · Oct 29, 2019Peer-reviewedMicrobiology

NK cells force cytomegalovirus to use hematopoietic cells and immune evasion for dissemination after mucosal infection

S. Zhang, F. Grey, C. M. Snyder

This study shows that MCMV uses hematopoietic cells and immune evasion genes to disseminate to the salivary gland after mucosal infection, with NK cells playing a critical role in this process.

bioRxiv · Apr 24, 2019 · PreprintImmunology