Author

T. J. Pullen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. Martinez-sanchez· 2 shared G. A. Rutter· 2 shared I. Leclerc· 2 shared A. M. J. Shapiro· 1 shared B. HASTOY· 1 shared B. Lenhard· 1 shared B. R. Gauthier· 1 shared D. A. Jacobson· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

A. Martinez-sanchez

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2 papers

Recent·Most cited

Roles for the long non-coding RNA Pax6os1/PAX6-AS1 in pancreatic beta cell identity and function.

L. Lopez-Noriega, R. M. Callingham, A. Martinez-sanchez, S. Nawaz, G. Pizza, N. Haberman, N. Cvetesic, M.-S. Nguyen-Tu, B. Lenhard, P. Marchetti, L. Piemonti, E. J. P. de Koning, A. M. J. Shapiro, P. R. Johnson, I. Leclerc, , G. A. Rutter

This study investigates the role of Pax6os1/PAX6-AS1 in beta cell identity and function, finding that its upregulation in diabetes contributes to impaired functionality and that targeting it may improve glucose homeostasis.

bioRxiv · Jul 17, 2020 · PreprintCell Biology

The mitochondrial Ca2+ uniporter MCU is required for normal glucose-stimulated insulin secretion in vitro and in vivo

E. Haythorne, E. Georgiadou, M. Dickerson, L. Lopez Noriega, T. J. Pullen, G. da Silva Xavier, S. Davis, A. Martinez-Sanchez, F. Semplici, R. Rizzuto, J. A. McGinty, P. M. French, M. C. Cane, D. A. Jacobson, I. Leclerc, G. A. Rutter

This study shows that the mitochondrial Ca2+ uniporter MCU is essential for normal glucose-stimulated insulin secretion in pancreatic beta-cells, both in vitro and in vivo.

bioRxiv · Sep 25, 2019Physiology