Author

T. Kane

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:organoid / primary culture· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Irizarry· 1 shared A. Petrin· 1 shared A. Sboner· 1 shared B. Bhinder· 1 shared B. Chamberlain· 1 shared B. K. Allen· 1 shared B. Tesar· 1 shared C. Bastos· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

A. Irizarry

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Novel co-culture strategies of tumor organoids with autologous T-cells reveal clinically relevant combinations of immune-checkpoint and targeted therapies

E. Podaza, J. Capuano, M. Al Assaad, H.-h. Kuo, G. Markowitz, A. Irizarry, H. Ravichandran, S. Ackermann, T. Kane, J. Manohar, M. Sigouros, J. Moyer, B. Bhinder, P. Chandra, M. Malbari, , M. L. Martin

The paper develops co-culture strategies of tumor organoids with autologous T-cells to screen immune-checkpoint and targeted therapy combinations.

bioRxiv · Jul 5, 2023 · PreprintImmunology

Design of a systemic small molecule clinical STING agonist using physics-based simulations and artificial intelligence

B. K. Allen, M. M. Kulkarni, B. Chamberlain, T. Dwight, C. Koh, R. Samant, F. Jernigan, J. Rice, D. Tan, S. Li, K. Marino, H. Huang, E. Chiswick, B. Tesar, S. Sparks, , W. Sherman

This paper designs a small molecule STING agonist, SNX281, using computational methods and AI, showing systemic activity and antitumor effects in mice.

bioRxiv · May 23, 2022 · PreprintCancer Biology

Discovery of genes encoding a Streptolysin S-like toxin biosynthetic cluster in a select highly pathogenic methicillin resistant Staphylococcus aureus JKD6159 strain

T. Kane, K. E. Carothers, Y. Bao, W.-S. Yeo, T. Bae, C. Park, F. R. Fields, H. M. Vu, D. E. Hammers, J. N. Ross, V. A. Ploplis, F. J. Castellino, S. W. Lee

The paper identifies a Streptolysin S-like toxin biosynthetic cluster in a highly pathogenic MRSA strain and investigates its potential role through genetic and phenotypic assays.

bioRxiv · Aug 31, 2019 · PreprintMicrobiology