Author

B. Bhinder

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

O. Elemento· 5 shared A. Sboner· 2 shared H. Ravichandran· 2 shared J. M. Mosquera· 2 shared J. Manohar· 2 shared K. W. Eng· 2 shared A. F. Rendeiro· 1 shared A. Irizarry· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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5 shared papersCancer Biology

O. Elemento

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Author profile →

5 papers

Recent·Most cited

The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization

S. Z. Hanif, C. C. Au, I. Torregroza, C. Kutz, S. Jannath, T. Fabiha, B. Bhinder, M. Washburn, D. Devost, S. Liu, P. Bhardwaj, T. Evans, P. K. Anand, R. Tarran, S. Palikhe, , K. A. Brown

This study shows that loss of GPR52 in breast cancer cells increases cell clustering, EMT features, and tumor burden in zebrafish, suggesting GPR52 as a potential therapeutic target.

bioRxiv · Jul 22, 2024 · PreprintCancer Biology

Novel co-culture strategies of tumor organoids with autologous T-cells reveal clinically relevant combinations of immune-checkpoint and targeted therapies

E. Podaza, J. Capuano, M. Al Assaad, H.-h. Kuo, G. Markowitz, A. Irizarry, H. Ravichandran, S. Ackermann, T. Kane, J. Manohar, M. Sigouros, J. Moyer, B. Bhinder, P. Chandra, M. Malbari, , M. L. Martin

The paper develops co-culture strategies of tumor organoids with autologous T-cells to screen immune-checkpoint and targeted therapy combinations.

bioRxiv · Jul 5, 2023 · PreprintImmunology

The evolution of genomic, transcriptomic, and single-cell protein markers of metastatic upper tract urothelial carcinoma

K. Ohara, A. F. Rendeiro, B. Bhinder, K. W. Eng, H. Ravichandran, D. Pisapia, A. Vosoughi, E. Fernandez, K. Shohdy, J. Manohar, S. Beg, D. Wilkes, B. Robinson, F. Khani, R. Bareja, , J. M. Mosquera

The paper examines genomic, transcriptomic, and single-cell protein markers in metastatic upper tract urothelial carcinoma, finding discordant genomic alterations but stable molecular and immune subtypes between primary and metastatic tumors.

bioRxiv · Nov 16, 2021 · PreprintCancer Biology

Molecular evolution of classic Hodgkin lymphoma revealed through whole genome sequencing of Hodgkin and Reed Sternberg cells

F. MAURA, B. Ziccheddu, J. J. Xiang, B. Bhinder, F. Abascal, K. Maclachlan, K. W. Eng, M. Uppal, F. He, W. Zhang, Q. Gao, V. Yellapantula, S. Park, M. Oberley, E. Ruckdeschel, , L. Giulino-Roth

This study uses whole genome sequencing of Hodgkin and Reed Sternberg cells to reconstruct the temporal evolution of classic Hodgkin lymphoma, identifying key mutations and structural variants.

bioRxiv · Nov 5, 2021Cancer Biology

Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production

E. K. Noch, L. Palma, I. Yim, D. Barnett, A. Walsh, B. Bhinder, E. Benedetti, J. Krumsiek, J. Gurvitch, S. Khwaja, O. Elemento, L. Cantley

This study shows that cysteine induces mitochondrial reductive stress in glioblastoma via hydrogen peroxide production, and NAC treatment reduces GBM cell growth.

bioRxiv · Sep 10, 2021 · PreprintCancer Biology