R. Hou

HIV-1 infection is associated with depletion of germinal center B cells and a decrease in IgA+ plasma cells in the GI tract

Spatial transcriptomics reveals ovarian cancer subclones with distinct tumour microenvironments

This study uses spatial and single-cell transcriptomics to identify ovarian cancer subclones with distinct microenvironments and infiltration patterns linked to treatment response.

Antimicrobial resistance, virulence genes profiles and molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae strains from captive giant pandas (Ailuropoda melanoleuca)

This study analyzed antibiotic resistance, virulence genes, and molecular epidemiology of CRKP strains from giant pandas, revealing diverse genetic profiles and high genetic diversity.

Modulation of Salmonella virulence by a novel SPI-2 injectisome effector that interacts with the dystrophin-associated protein complex.

This paper identifies a novel SPI-2 effector, SseM, in Salmonella that interacts with the dystrophin-associated protein complex and modulates bacterial growth in mice.

CSTA: A Biomarker Regulating Esophageal Stricture Epithelial Barrier, Potential Medication Target

The paper identifies CSTA as a biomarker for esophageal epithelial barrier function and shows FK506 can rescue CSTA-knockdown effects in strictures.

Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein driving the genesis of Omicron variants

The paper identifies public antibodies using VL6-57 light chains that target a conserved epitope on SARS-CoV-2 spike protein, showing how Omicron variants evolved to escape these antibodies.

Myeloid cell influx into the colonic epithelium is associated with disease severity and non-response to anti-Tumor Necrosis Factor Therapy in patients with Ulcerative Colitis.

The paper identifies myeloid cell influx and epithelial cell perturbations in ulcerative colitis, linking them to disease severity and anti-TNF therapy non-response.

Angiopoietin-like 4 promotes the proliferation and migration of epidermal stem cells and contributes to the re-epithelialization of cutaneous wounds

This study shows ANGPTL4 promotes epidermal stem cell proliferation and migration, enhancing wound re-epithelialization in mice.

Evolutionary survival strategies of the female giant panda: optimizing energy resources and expenditure prior to pregnancy by postponing corpus luteum reactivation

This study investigates giant panda reproductive physiology, finding that pregnancy lasts 42 days and involves a triphasic progesterone profile with CL reactivation postponed to shorten the active luteal phase.

Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer

This study identifies diverse stromal subsets in TNBC using single-cell RNA-seq and links them to immune evasion mechanisms and therapeutic targets.

Prostaglandin receptor EP2 is a novel molecular target for high-risk neuroblastoma

This study identifies EP2 as a key PGE2 receptor promoting neuroblastoma growth and shows that targeting it with small-molecule antagonists inhibits tumor growth in mice.